INT198015

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 5.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BAK1, MCL1) cell differentiation (MCL1) nucleoplasm (MCL1)
aging (BAK1) endoplasmic reticulum (BAK1) intracellular (BAK1)
BAK1 (Homo sapiens)
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 12 49.84 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 648 100.00 Very High Very High Very High
Carcinoma 564 99.96 Very High Very High Very High
Leukemia 24 83.48 Quite High
Cancer 126 65.28 Quite High
Malignant Neoplastic Disease 6 63.96 Quite High
Multiple Myeloma 18 63.28 Quite High
Lung Cancer 18 61.52 Quite High
Metastasis 6 58.88 Quite High
Colon Cancer 12 57.76 Quite High
Disease 6 51.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mcl-1 is known to interact with Bak [13].
Bak Binding (interact) of Mcl-1
1) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.81 Pain Relevance 0
An important mode of action of Mcl-1 is the interaction with pro-apoptotic Bcl-2 family members (such as Bim [60], Bak, Bid and Bax).
Bak Binding (interaction) of Mcl-1 associated with apoptosis
2) Confidence 0.23 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.82 Pain Relevance 0
However, since p53 mutations are frequently found in HCC, Mcl-1-Bak interaction might be more stable in HCC, resulting in a stabilization of mitochondria.
Bak Binding (interaction) of Mcl-1 associated with carcinoma
3) Confidence 0.22 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.76 Pain Relevance 0
However, since p53 mutations are frequently found in HCC, Mcl-1-Bak interaction might be more stable in HCC, resulting in a stabilization of mitochondria.
Bak Binding (interaction) of Mcl-1 associated with carcinoma
4) Confidence 0.22 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.76 Pain Relevance 0
An important mode of action of Mcl-1 is the interaction with pro-apoptotic Bcl-2 family members (such as Bim [60], Bak, Bid and Bax).
pro-apoptotic Binding (interaction) of Mcl-1 associated with apoptosis
5) Confidence 0.20 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.82 Pain Relevance 0
Mcl-1 blocks cytochrome c-release from mitochondria by interacting with pro-apoptotic members of the Bcl-2 protein family, e.g.
pro-apoptotic Binding (interacting) of Mcl-1 associated with apoptosis
6) Confidence 0.19 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.20 Pain Relevance 0

General Comments

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