INT198021

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BCL2, MCL1) cytoplasm (BCL2, MCL1) nucleus (BCL2, MCL1)
cell differentiation (MCL1) nucleoplasm (MCL1) cell morphogenesis (BCL2)
BCL2 (Homo sapiens)
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 6 49.84 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 324 100.00 Very High Very High Very High
Carcinoma 282 96.44 Very High Very High Very High
Leukemia 12 83.48 Quite High
Cancer 63 66.96 Quite High
Multiple Myeloma 9 64.96 Quite High
Malignant Neoplastic Disease 3 63.96 Quite High
Lung Cancer 9 63.20 Quite High
Metastasis 3 60.56 Quite High
Colon Cancer 6 59.44 Quite High
Disease 3 53.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heterodimerization of Mcl-1 with proapoptotic Bcl-2 family members can neutralize their proapoptotic properties.
Bcl-2 Binding (Heterodimerization) of Mcl-1
1) Confidence 0.17 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.85 Pain Relevance 0
An important mode of action of Mcl-1 is the interaction with pro-apoptotic Bcl-2 family members (such as Bim [60], Bak, Bid and Bax).
Bcl-2 Binding (interaction) of Mcl-1 associated with apoptosis
2) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.82 Pain Relevance 0
Mcl-1 blocks cytochrome c-release from mitochondria by interacting with pro-apoptotic members of the Bcl-2 protein family, e.g.
Bcl-2 Binding (interacting) of Mcl-1 associated with apoptosis
3) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.21 Pain Relevance 0

General Comments

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