INT198027

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Context Info
Confidence 0.72
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 7.46
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
Anatomy Link Frequency
nucleus 1
lobes 1
heart 1
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 99.98 Very High Very High Very High
Inflammation 9 94.76 High High
Nerve growth factor 1 93.84 High High
Central nervous system 1 93.08 High High
ischemia 4 84.20 Quite High
palliative 4 57.12 Quite High
imagery 12 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 433 100.00 Very High Very High Very High
Hepatocellular Cancer 18 99.92 Very High Very High Very High
INFLAMMATION 11 99.78 Very High Very High Very High
Heart Rate Under Development 102 99.02 Very High Very High Very High
Cognitive Disorder 14 97.36 Very High Very High Very High
Carcinoma 188 97.28 Very High Very High Very High
Myocardial Infarction 32 93.64 High High
Necrosis 3 91.32 High High
Apoptosis 216 91.28 High High
Cancer 43 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to Bcl-2, Mcl-1 is not only found in mitochondrial membranes, but also in the nucleus and cytoplasm [11].
Localization (found) of Mcl-1 in nucleus
1) Confidence 0.72 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.90 Pain Relevance 0.06
Targeting of Mcl-1 via RNA interference is a potential therapeutic strategy to render HCC cells more sensitive to chemotherapy and molecularly targeted treatment regimens.


Localization (Targeting) of Mcl-1 associated with carcinoma
2) Confidence 0.72 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.64 Pain Relevance 0
With decreasing LV-EF, CHF patients showed an decrease in LVRI and indexed EAT increase resulting in an increasing indexed-EAT-LVRI ratio, indicating a remodelling not compensated by an adequate EAT increase.
Localization (increase) of EAT associated with heart rate under development and obesity
3) Confidence 0.54 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.69 Pain Relevance 0
The regulation and metabolism of pro- and anti-inflammatory mediators secreted by EAT have been linked to insulin sensitivity [23].
Localization (secreted) of EAT associated with inflammatory mediators and obesity
4) Confidence 0.54 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 2.38 Pain Relevance 0.36
These results are in line with a post-mortem study by Schejbal V. et al. [18] who also found significantly less EAT in patients with signs of congestive heart failure.
Localization (found) of EAT in heart associated with heart rate under development and obesity
5) Confidence 0.51 Published 2010 Journal J Cardiovasc Magn Reson Section Body Doc Link PMC2914772 Disease Relevance 1.57 Pain Relevance 0.04
Similarly, various EEG changes found in TM are unique, e.g. alpha waves spreading forwards from the occipital lobes to the front and dominating the entire brain cortex.
Localization (found) of TM in lobes
6) Confidence 0.17 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1697747 Disease Relevance 0.29 Pain Relevance 0.05

General Comments

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