INT198032

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.21
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 8.16
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 4
HCC (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 24 58.24 Quite High
fibrosis 32 36.08 Quite Low
Bile 8 27.44 Quite Low
palliative 4 9.92 Low Low
antagonist 8 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 312 100.00 Very High Very High Very High
Hepatocellular Cancer 214 100.00 Very High Very High Very High
Carcinoma 97 100.00 Very High Very High Very High
Metastasis 34 99.56 Very High Very High Very High
Liver Cancer 30 98.12 Very High Very High Very High
Targeted Disruption 4 97.52 Very High Very High Very High
Chronic Hepatitis 2 97.48 Very High Very High Very High
Cancer 193 96.64 Very High Very High Very High
Cirrhosis 60 96.24 Very High Very High Very High
Hepatitis Virus Infection 12 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we applied RNA interference to downregulate Mcl-1 expression in the HCC cell line Huh7.
Negative_regulation (downregulate) of Gene_expression (expression) of HCC associated with carcinoma
1) Confidence 0.21 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.29 Pain Relevance 0
Because promoter methylation is significantly enhanced in HCC compared to that of non-tumor samples, and APC expression is also significantly reduced in liver cancer cells, higher degrees of promoter methylation of the APC gene seem to be responsible for the reduced APC protein expression in HCC.
Negative_regulation (reduced) of Gene_expression (expression) of HCC in liver associated with liver cancer, cancer, familial adenomatous polyposis and hepatocellular cancer
2) Confidence 0.11 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.75 Pain Relevance 0
Lower panel: results from reverse sequencing

Detection of APC protein expression in HCC and liver metastasis

Negative_regulation (reverse) of Gene_expression (expression) of HCC in liver associated with hepatocellular cancer, familial adenomatous polyposis and metastasis
3) Confidence 0.11 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 1.42 Pain Relevance 0
This finding reflects the overall reduced expression of the APC protein in patients with HCC.
Negative_regulation (reduced) of Gene_expression (expression) of HCC associated with hepatocellular cancer and familial adenomatous polyposis
4) Confidence 0.11 Published 2007 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2757596 Disease Relevance 2.07 Pain Relevance 0
concentration, either inhibited the appearance of HCC, or decreased the growth
Negative_regulation (inhibited) of Gene_expression (appearance) of HCC associated with hepatocellular cancer
5) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.58 Pain Relevance 0
expression in HCC compared
Negative_regulation (compared) of Gene_expression (expression) of HCC associated with hepatocellular cancer
6) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 1.05 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox