INT198036

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Context Info
Confidence 0.27
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.98
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BAK1) mitochondrion (BAK1) aging (BAK1)
endoplasmic reticulum (BAK1) intracellular (BAK1)
BAK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 29 85.68 High High
COX-2 inhibitor 60 67.40 Quite High
antagonist 13 54.76 Quite High
cINOD 20 23.48 Low Low
metalloproteinase 29 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
Nerve growth factor 5 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 401 100.00 Very High Very High Very High
Carcinoma 117 99.84 Very High Very High Very High
Stress 17 99.02 Very High Very High Very High
Cancer 275 98.64 Very High Very High Very High
Colon Cancer 77 97.92 Very High Very High Very High
Non-small-cell Lung Cancer 3 95.44 Very High Very High Very High
Fever 42 92.16 High High
Lung Cancer 146 91.84 High High
INFLAMMATION 32 85.68 High High
Skin Cancer 8 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antiapoptotic protein Bcl-2 and inactive phosphorylated form of Bad (Figures 1 and 2) were increased in all cancer specimens, with no differences among Duke's stages, whereas the proapototic proteins Bad and Bak were decreased (Figure 2).


Negative_regulation (decreased) of Bak associated with cancer
1) Confidence 0.27 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2762309 Disease Relevance 0.57 Pain Relevance 0
The molecular mechanisms that mediate the pro-apoptotic effect of Mcl-1 downregulation in HCC cells remain elusive and are subject to further studies.
Negative_regulation (downregulation) of pro-apoptotic associated with carcinoma and apoptosis
2) Confidence 0.21 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.98 Pain Relevance 0
This effect was due to a down-regulation of MnSOD (superoxide dismutase containing manganese (Mn) and localized in mitochondria), a primary antioxidant protein and survivin, an anti-apoptotic protein (IAPS family member).
Negative_regulation (regulation) of anti-apoptotic protein associated with apoptosis
3) Confidence 0.18 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.22 Pain Relevance 0.07
decreased; (4) the antiapoptotic proteins Bcl-2 and pBad increased, whereas the proapototic proteins Bad and Bak decreased.
Negative_regulation (decreased) of Bak
4) Confidence 0.14 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2762309 Disease Relevance 0.97 Pain Relevance 0.09
Our data are consistent with the idea that an increased antioxidant capacity and modulated oxidative stress from strenuous physical load may be involved in reducing pro-apoptotic genes.
Negative_regulation (reducing) of pro-apoptotic associated with stress and apoptosis
5) Confidence 0.03 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.85 Pain Relevance 0
A recent study similarly showed co-expression of the anti-apoptotic proteins Bcl-2, Bcl-XL and Mcl-1, with variable loss of expression of the anti-apoptotic Bad, Bak, Bax, Bid and Bim (O’Kane, 2006).
Spec (analyzed) Negative_regulation (loss) of Bak associated with apoptosis
6) Confidence 0.02 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.38 Pain Relevance 0

General Comments

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