INT198036

Context Info Confidence 0.27 First Reported 2006 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 6 Disease Relevance 5.98 Pain Relevance 0.17

cytosol (BAK1) mitochondrion (BAK1) aging (BAK1) endoplasmic reticulum (BAK1) intracellular (BAK1)

BAK1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 29 85.68 COX-2 inhibitor 60 67.40 antagonist 13 54.76 cINOD 20 23.48 metalloproteinase 29 5.00 cytokine 13 5.00 chemokine 9 5.00 Nerve growth factor 5 5.00 aspirin 4 5.00 alcohol 3 5.00

Disease Link Frequency Relevance Heat Apoptosis 401 100.00 Carcinoma 117 99.84 Stress 17 99.02 Cancer 275 98.64 Colon Cancer 77 97.92 Non-small-cell Lung Cancer 3 95.44 Fever 42 92.16 Lung Cancer 146 91.84 INFLAMMATION 32 85.68 Skin Cancer 8 76.72

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The antiapoptotic protein Bcl-2 and inactive phosphorylated form of Bad (Figures 1 and 2) were increased in all cancer specimens, with no differences among Duke's stages, whereas the proapototic proteins Bad and Bak were decreased (Figure 2).

Negative_regulation (decreased) of Bak associated with cancer

1) Confidence 0.27 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2762309 Disease Relevance 0.57 Pain Relevance 0

The molecular mechanisms that mediate the pro-apoptotic effect of Mcl-1 downregulation in HCC cells remain elusive and are subject to further studies.

Negative_regulation (downregulation) of pro-apoptotic associated with carcinoma and apoptosis

2) Confidence 0.21 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.98 Pain Relevance 0

This effect was due to a down-regulation of MnSOD (superoxide dismutase containing manganese (Mn) and localized in mitochondria), a primary antioxidant protein and survivin, an anti-apoptotic protein (IAPS family member).

Negative_regulation (regulation) of anti-apoptotic protein associated with apoptosis

3) Confidence 0.18 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.22 Pain Relevance 0.07

decreased; (4) the antiapoptotic proteins Bcl-2 and pBad increased, whereas the proapototic proteins Bad and Bak decreased.

Negative_regulation (decreased) of Bak

4) Confidence 0.14 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2762309 Disease Relevance 0.97 Pain Relevance 0.09

Our data are consistent with the idea that an increased antioxidant capacity and modulated oxidative stress from strenuous physical load may be involved in reducing pro-apoptotic genes.

Negative_regulation (reducing) of pro-apoptotic associated with stress and apoptosis

5) Confidence 0.03 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.85 Pain Relevance 0

A recent study similarly showed co-expression of the anti-apoptotic proteins Bcl-2, Bcl-XL and Mcl-1, with variable loss of expression of the anti-apoptotic Bad, Bak, Bax, Bid and Bim (O’Kane, 2006).

Spec (analyzed) Negative_regulation (loss) of Bak associated with apoptosis

6) Confidence 0.02 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.38 Pain Relevance 0

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