INT198037

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Context Info
Confidence 0.28
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.63
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA) signal transduction (PIK3CA)
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 4 50.00 Quite Low
Inflammation 15 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 153 100.00 Very High Very High Very High
Carcinoma 155 99.84 Very High Very High Very High
Microsatellite Instability 47 98.84 Very High Very High Very High
Aneuploidy 3 96.32 Very High Very High Very High
Apoptosis 124 94.00 High High
Chromosomal Instability 1 92.08 High High
Endometroid Carcinoma 21 71.68 Quite High
Cancer 106 67.28 Quite High
Death 10 62.84 Quite High
Lung Cancer 3 53.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an endeavour to understand further the mechanism through which arachidonic acid acts, we investigated whether it affected the activity of phosphatidylinositol 3-kinase (PI3K).
Spec (whether) Regulation (affected) of PI3K
1) Confidence 0.28 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
One of the downstream targets of Akt is the serine/threonine kinase mTOR which is a promising candidate target in the PI3K/Akt pathway in HCC [43].
Regulation (pathway) of PI3K associated with carcinoma
2) Confidence 0.24 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.08 Pain Relevance 0
Furthermore, none of the five main alterations of endometrioid endometrial carcinoma (mutations of PTEN, PIK3CA, KRAS, and CTNNB1 genes and MSI) plays a major role in non-endometrioid endometrial carcinoma.
Regulation (alterations) of PIK3CA associated with microsatellite instability and endometrial cancer
3) Confidence 0.22 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.56 Pain Relevance 0

General Comments

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