INT198040

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCL2L11) mitochondrion (BCL2L11) plasma membrane (BCL2L11)
cytoplasm (BCL2L11)
Anatomy Link Frequency
cleavage 1
BCL2L11 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 605 99.88 Very High Very High Very High
Carcinoma 191 85.84 High High
Reprotox - General 1 20 84.84 Quite High
Neuroblastoma 6 84.16 Quite High
Cancer 98 64.40 Quite High
Stress 33 62.64 Quite High
Coronary Artery Disease 1 52.92 Quite High
Papillomavirus Infection 1 51.88 Quite High
Cervical Cancer 3 50.36 Quite High
Disease 141 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the up-regulation of miR-34a and miR-195 was associated with a down-regulation of BCL2 and SGK1 protein levels, respectively; whereas the down-regulation of miR-193b, miR-221, miR-222 and miR-7 was associated with an up-regulation of MCL1, BCL2L11 (Bim), CDN1B (p 27) and VDAC1 protein levels, respectively (Figure 9A).
Positive_regulation (up-regulation) of BCL2L11
1) Confidence 0.40 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.47 Pain Relevance 0
For example, the up-regulation of miR-34a and miR-195 was associated with a down-regulation of BCL2 and SGK1 protein levels, respectively; whereas the down-regulation of miR-193b, miR-221, miR-222 and miR-7 was associated with an up-regulation of MCL1, BCL2L11 (Bim), CDN1B (p 27) and VDAC1 protein levels, respectively (Figure 9A).
Positive_regulation (up-regulation) of Bim
2) Confidence 0.40 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.47 Pain Relevance 0
The pro-apoptotic BAX, BCL2L11, BID, BNIP3L, and BOK proteins [78] were all induced in WTSTS cells as well.
Positive_regulation (induced) of BCL2L11 associated with apoptosis
3) Confidence 0.22 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.49 Pain Relevance 0
After knockdown of Mcl-1 by RNAi, levels of free Bim might be increased which in turn may lead to activation of Bax.
Positive_regulation (increased) of Bim
4) Confidence 0.15 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.89 Pain Relevance 0
Elevated levels of free Bim might sensitize cells to apoptotic stimuli such as chemotherapy.
Positive_regulation (levels) of Bim associated with apoptosis
5) Confidence 0.14 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.83 Pain Relevance 0
Bid and Bim can be also activated by a direct cleavage by caspase-8, as well as by the lysosomal protease cathepsin, in response to ceramide, ROS and JNK.
Positive_regulation (activated) of Bim in cleavage
6) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.34 Pain Relevance 0

General Comments

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