INT198042

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 10.05
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
Anatomy Link Frequency
endothelial cells 3
liver 2
fibroblasts 1
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 80 99.48 Very High Very High Very High
Osteoarthritis 42 99.08 Very High Very High Very High
palliative 14 76.08 Quite High
Arthritis 54 50.88 Quite High
Kinase C 4 32.00 Quite Low
chemokine 14 28.28 Quite Low
Inflammatory mediators 6 26.08 Quite Low
Inflammation 22 5.00 Very Low Very Low Very Low
Bioavailability 18 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 658 100.00 Very High Very High Very High
Apoptosis 790 99.80 Very High Very High Very High
Rheumatoid Arthritis 80 99.48 Very High Very High Very High
Osteoarthritis 42 99.08 Very High Very High Very High
Targeted Disruption 28 91.44 High High
Leukemia 32 90.68 High High
Cancer 155 83.48 Quite High
Hepatitis 7 72.96 Quite High
Death 49 68.32 Quite High
Myeloid Leukemia 7 68.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, transfection of chemically synthesized siRNA had a fast inhibitory effect on Mcl-1 expression in HCC cells in vitro. 24 h after transfection of HCC cells with siRNA, Mcl-1 expression was profoundly reduced. siRNA can also be applied in animals in vivo by intravenous or local injection.
Regulation (effect) of Gene_expression (expression) of Mcl-1 associated with carcinoma
1) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.13 Pain Relevance 0
As in Hep3B cells, we found that MEK1 inhibition did not influence Mcl-1 expression in these cell lines (Fig. 2A).
Neg (not) Regulation (influence) of Gene_expression (expression) of Mcl-1
2) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.93 Pain Relevance 0
In the current study, transfection of chemically synthesized siRNA had a fast inhibitory effect on Mcl-1 expression in HCC cells in vitro. 24 h after transfection of HCC cells with siRNA, Mcl-1 expression was profoundly reduced. siRNA can also be applied in animals in vivo by intravenous or local injection.
Regulation (effect) of Gene_expression (expression) of Mcl-1 associated with carcinoma
3) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.10 Pain Relevance 0
In this study we tested the effect of PI3K inhibition on Mcl-1 expression and apoptosis sensitivity in the HCC cell line Huh7.
Regulation (effect) of Gene_expression (expression) of Mcl-1 associated with carcinoma and apoptosis
4) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.96 Pain Relevance 0
M, 1–6 h) influenced Mcl-1 expression in Huh7 cells (data not shown).
Regulation (influenced) of Gene_expression (expression) of Mcl-1
5) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.90 Pain Relevance 0
One approach to influence Mcl-1 expression in liver cells is by blocking kinase signaling pathways.
Regulation (influence) of Gene_expression (expression) of Mcl-1 in liver
6) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.90 Pain Relevance 0.05
In this study, we first sought to explore the sensitivity of Mcl-1 expressing HCC cell lines to chemotherapeutic drug-induced apoptosis.
Regulation (sensitivity) of Gene_expression (expressing) of Mcl-1 associated with carcinoma and apoptosis
7) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.01 Pain Relevance 0.08
Importantly, EGCG specifically abrogated Mcl-1 expression in RA synovial fibroblasts and affected Mcl-1 expression to a lesser extent in OA synovial fibroblasts, normal synovial fibroblasts, and endothelial cells.
Regulation (affected) of Gene_expression (expression) of Mcl-1 in endothelial cells associated with rheumatoid arthritis and osteoarthritis
8) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.56 Pain Relevance 0.48
Importantly, EGCG specifically abrogated Mcl-1 expression in RA synovial fibroblasts and affected Mcl-1 expression to a lesser extent in OA synovial fibroblasts, normal synovial fibroblasts, and endothelial cells.
Regulation (affected) of in fibroblasts Gene_expression (expression) of Mcl-1 in endothelial cells associated with rheumatoid arthritis and osteoarthritis
9) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.56 Pain Relevance 0.48

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