INT198046

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2006
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 324 100.00 Very High Very High Very High
Carcinoma 282 94.32 High High
Hepatocellular Cancer 27 89.84 High High
Death 21 76.40 Quite High
Cancer 63 75.96 Quite High
Injury 3 68.36 Quite High
Lung Cancer 9 66.56 Quite High
Hepatitis 3 63.60 Quite High
Sarcoma 6 55.44 Quite High
Skin Cancer 6 54.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, after specific downregulation of Mcl-1 by RNA interference, apoptosis was induced (17.2% after 24 h, p < 0.001) (Fig. 4).
Positive_regulation (induced) of Negative_regulation (downregulation) of Mcl-1 associated with apoptosis
1) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.90 Pain Relevance 0
It is not likely due to a more effective knockdown of Mcl-1 by ASO application: 24 to 72 h after transfection with Mcl-1 siRNA, virtually no Mcl-1 expression could be detected by Western blot analysis in our study.
Neg (not) Spec (likely) Positive_regulation (due) of Negative_regulation (knockdown) of Mcl-1
2) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.92 Pain Relevance 0
Downregulation of Mcl-1 significantly enhanced apoptosis induced by PI3K inhibition.
Positive_regulation (induced) of Negative_regulation (Downregulation) of Mcl-1 associated with apoptosis
3) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.23 Pain Relevance 0

General Comments

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