INT19805

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Context Info
Confidence 0.59
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 4.57
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
signal transducer activity (Avp)
Anatomy Link Frequency
hypothalamus 2
brain structure 2
pituitary 1
uterine 1
gland 1
Avp (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 5 100.00 Very High Very High Very High
narcan 6 99.84 Very High Very High Very High
dexamethasone 55 99.50 Very High Very High Very High
Morphine 24 98.56 Very High Very High Very High
Opioid 4 98.56 Very High Very High Very High
tolerance 22 98.08 Very High Very High Very High
substance P 2 98.08 Very High Very High Very High
withdrawal 1 98.08 Very High Very High Very High
Hippocampus 17 97.52 Very High Very High Very High
Intracerebroventricular 9 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Insipidus 12 99.68 Very High Very High Very High
Convulsion 1 99.56 Very High Very High Very High
Opiate Addiction 1 98.08 Very High Very High Very High
Hypoxia 4 98.00 Very High Very High Very High
Polyuria 6 97.88 Very High Very High Very High
Stress 187 95.40 Very High Very High Very High
Amnesia 8 95.32 Very High Very High Very High
Anxiety Disorder 192 94.24 High High
Adrenal Insufficiency 12 93.32 High High
Hyponatremia 30 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the latter brain structure of the tolerant animals, the AVP content was also decreased.
Negative_regulation (decreased) of AVP in brain structure
1) Confidence 0.59 Published 1987 Journal Exp Brain Res Section Abstract Doc Link 3556459 Disease Relevance 0.10 Pain Relevance 0.86
Analysis of genome wide expression revealed a significantly decreased Avp mRNA level in the PVN (p<0.05) and showed a tendency towards the same direction in the SON (p<0.1) of LAB compared to HAB mice.
Negative_regulation (decreased) of Avp mRNA
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.60 Pain Relevance 0.09
Confirming ISH data, these experiments showed a decreased amount of AVP peptide in LAB compared to HAB mice in the PVN (Fig. 3).
Negative_regulation (decreased) of AVP peptide
3) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.57 Pain Relevance 0.10
Vasotocin analogues which competitively inhibit vasopressin stimulated uterine activity in healthy women.
Negative_regulation (inhibit) of vasopressin in uterine
4) Confidence 0.58 Published 1986 Journal Br J Obstet Gynaecol Section Title Doc Link 3942702 Disease Relevance 0.37 Pain Relevance 0.22
We had previously found that chronic ethanol ingestion resulted in decreased levels of hypothalamic and extrahypothalamic vasopressin mRNA, and the current study investigated the effect of ethanol ingestion on prodynorphin mRNA levels.
Negative_regulation (decreased) of vasopressin
5) Confidence 0.46 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255170 Disease Relevance 0 Pain Relevance 0.09
Thus, amnesic model mice are deficient in brain AVP levels, and consequently, a certain level of AVP in the hypothalamus is required for maintaining the normal function such as the development of tolerance to morphine and the recovery from amnesia.
Negative_regulation (deficient) of AVP in hypothalamus associated with tolerance, amnesia and morphine
6) Confidence 0.43 Published 1993 Journal Brain Res. Section Abstract Doc Link 8508324 Disease Relevance 0.56 Pain Relevance 0.85
Taken together, these data indicate that Bi-proVSP is produced in the venom gland, gets cleaved into its 34-kDa active form (mature Bi-VSP), and is then stored in the venom sac.


Negative_regulation (stored) of VSP in gland
7) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2862700 Disease Relevance 0 Pain Relevance 0
In all amnesic groups, radioimmunoassayable AVP content in hypothalamus was decreased, in particular, the reduction was significant in hypoxia and ischemic induced amnesic animals, then recovered to the control level by 20 days after each treatment.
Negative_regulation (decreased) of AVP in hypothalamus associated with hypoxia
8) Confidence 0.38 Published 1993 Journal Brain Res. Section Abstract Doc Link 8508324 Disease Relevance 0.57 Pain Relevance 0.76
The radioimmunoassayable arginine vasopressin content was decreased in the hypothalamus but not in other regions of mouse brain after exposure to an acute footshock or psychological stress.
Neg (not) Negative_regulation (decreased) of vasopressin in brain associated with stress
9) Confidence 0.37 Published 1990 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2095715 Disease Relevance 0.39 Pain Relevance 0.84
VP analgesia was eliminated by pretreatment with 1-deamino-penicillamine-2(O-methyl)tyrosine-AVP (dPTyr(me)AVP: 500 ng, ICV), a VP antagonist, but not naloxone (1 or 10 micrograms, ICV), suggesting that VP modulates nonciceptive thresholds through its own binding sites.
Negative_regulation (eliminated) of VP associated with antagonist, narcan, intracerebroventricular and analgesia
10) Confidence 0.35 Published 1984 Journal Peptides Section Abstract Doc Link 6494025 Disease Relevance 0.19 Pain Relevance 1.33
A nonapeptide derived by reading of the complementary DNA strand of the bovine AVP gene in the 3' to 5' direction specifically blocks the AVP helper signal for interferon-gamma production by mouse T lymphocytes.
Negative_regulation (reading) of AVP in T lymphocytes
11) Confidence 0.34 Published 1994 Journal Immunomethods Section Abstract Doc Link 7874440 Disease Relevance 0 Pain Relevance 0.19
This suppressive effect still remains in the mutated construct in which two putative CREs are eliminated, suggesting that glucocorticoid reduces the vasopressin promoter activity independently of CREs.
Negative_regulation (reduces) of vasopressin promoter
12) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.09
In hypothalamic organotypic slice culture, it has been confirmed that dexamethasone treatment significantly suppresses the vasopressin gene mRNA in PVN, but not SCN (Kuwahara et al. 2003.)
Negative_regulation (suppresses) of vasopressin gene mRNA associated with dexamethasone
13) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.33 Pain Relevance 0.15
Therefore, vasopressin deficiency causes central diabetes insipidus (CDI) with marked polyuria at an amount of more than 10 liters per day.
Negative_regulation (deficiency) of vasopressin associated with polyuria and diabetes insipidus
14) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.28 Pain Relevance 0.09
The vasopressin gene promoter activity is suppressed through this element, after dexamethasone treatment.
Negative_regulation (suppressed) of vasopressin gene promoter associated with dexamethasone
15) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.09
It is possible that GC reduces the CRH or vasopressin gene promoter activity, due to the inhibition of the activation of these transcription factors or signaling pathways at the transcriptional or posttranscriptional level.
Negative_regulation (reduces) of vasopressin gene promoter
16) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.07
The AP1 site we identified is the sole responsible element for Fos/Jun proteins, because the AP1-induced potent transcription activity of the vasopressin gene is completely abolished when the AP1 site is altered.
Negative_regulation (abolished) of vasopressin gene
17) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.23 Pain Relevance 0.06
The inhibitory effect of chronic osmotic stimulation on ACTH secretion in spite of high circulating levels of VP is probably the result of diminished activity of parvicellular PVN neurons and downregulation of pituitary VP receptors.
Negative_regulation (downregulation) of VP in pituitary
18) Confidence 0.04 Published 1994 Journal Front Neuroendocrinol Section Abstract Doc Link 7895891 Disease Relevance 0.39 Pain Relevance 0

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