INT198051

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 282 100.00 Very High Very High Very High
Apoptosis 324 98.64 Very High Very High Very High
Lung Cancer 9 89.32 High High
Multiple Myeloma 9 88.08 High High
Targeted Disruption 12 86.68 High High
Cancer 63 83.44 Quite High
Hepatocellular Cancer 27 82.80 Quite High
Necrosis 3 80.24 Quite High
Immunotherapy Of Cancer 6 78.28 Quite High
Skin Cancer 6 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sensitizing HCC cells towards combined treatment modalities after downregulation of Mcl-1
Regulation (Sensitizing) of Negative_regulation (downregulation) of Mcl-1 associated with carcinoma
1) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.03 Pain Relevance 0
Our results demonstrate that a specific knockdown of Mcl-1 by RNAi sensitizes HCC cells to chemotherapeutic drugs, such as epirubicin, mitomycin C and 5-FU.
Regulation (sensitizes) of Negative_regulation (knockdown) of Mcl-1 associated with carcinoma
2) Confidence 0.43 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.63 Pain Relevance 0
Next, we tested the effect of Mcl-1 downregulation on chemotherapeutic drug-induced apoptosis of HCC cells.
Regulation (effect) of Negative_regulation (downregulation) of Mcl-1 associated with carcinoma and apoptosis
3) Confidence 0.26 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.39 Pain Relevance 0

General Comments

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