INT198052

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 24.19
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (MCL1) nucleoplasm (MCL1) mitochondrion (MCL1)
nucleus (MCL1) cytoplasm (MCL1)
Anatomy Link Frequency
hepatocytes 2
lung 2
MCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 40 97.64 Very High Very High Very High
imagery 9 97.16 Very High Very High Very High
Osteoarthritis 21 88.48 High High
Arthritis 27 50.00 Quite Low
Kinase C 2 37.12 Quite Low
Angina 6 36.20 Quite Low
chemokine 7 33.40 Quite Low
cytokine 7 29.36 Quite Low
Inflammatory mediators 9 16.40 Low Low
Inflammation 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1207 100.00 Very High Very High Very High
Obesity 613 100.00 Very High Very High Very High
Targeted Disruption 40 100.00 Very High Very High Very High
Carcinoma 946 99.92 Very High Very High Very High
Cancer 404 99.44 Very High Very High Very High
Metabolic Syndrome 162 99.28 Very High Very High Very High
Coronary Artery Disease 153 99.00 Very High Very High Very High
Immunotherapy Of Cancer 20 98.52 Very High Very High Very High
Rheumatoid Arthritis 40 97.64 Very High Very High Very High
Multiple Myeloma 39 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection with Mcl-1 specific siRNA led to a profound decrease of Mcl-1 expression on mRNA as well as protein level already 24 h after transfection and continues for at least 72 h (Fig. 3A).
Positive_regulation (Transfection) of Gene_expression (Transfection) of Mcl-1
1) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.33 Pain Relevance 0
Sensitizing HCC cells towards chemotherapeutic drug-induced apoptosis by RNAi of Mcl-1 expression
Positive_regulation (induced) of Gene_expression (expression) of Mcl-1 associated with carcinoma and apoptosis
2) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.28 Pain Relevance 0
We have already shown that the PI3K/Akt pathway induces Mcl-1 expression in human hepatocytes [33].
Positive_regulation (induces) of Gene_expression (expression) of Mcl-1 in hepatocytes
3) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.23 Pain Relevance 0
The molecular mechanisms that mediate the pro-apoptotic effect of Mcl-1 downregulation in HCC cells remain elusive and are subject to further studies.
Positive_regulation (mediate) of Gene_expression (effect) of Mcl-1 associated with carcinoma and apoptosis
4) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.98 Pain Relevance 0
g/ml, 24 h) was enhanced from 15% (cells transfected with control siRNA) to 32% (cells transfected with Mcl-1 siRNA, p < 0.001).
Positive_regulation (transfected) of Gene_expression (transfected) of Mcl-1 siRNA
5) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.70 Pain Relevance 0
It is not likely due to a more effective knockdown of Mcl-1 by ASO application: 24 to 72 h after transfection with Mcl-1 siRNA, virtually no Mcl-1 expression could be detected by Western blot analysis in our study.
Positive_regulation (transfection) of Gene_expression (transfection) of Mcl-1 siRNA
6) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.92 Pain Relevance 0
M, 1–6 h) influenced Mcl-1 expression in Huh7 cells (data not shown).
Positive_regulation (influenced) of Gene_expression (expression) of Mcl-1
7) Confidence 0.48 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.90 Pain Relevance 0
As seen in Figure 3, survivors of 2 years, 53.8% had a positive Mcl-1 expression, while only 10.0% of those cases that did not survive showed positive Mcl-1 expression.
Positive_regulation (positive) of Gene_expression (expression) of Mcl-1
8) Confidence 0.47 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.31 Pain Relevance 0
As seen in Figure 3, survivors of 2 years, 53.8% had a positive Mcl-1 expression, while only 10.0% of those cases that did not survive showed positive Mcl-1 expression.
Positive_regulation (positive) of Gene_expression (expression) of Mcl-1
9) Confidence 0.47 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2913917 Disease Relevance 0.27 Pain Relevance 0
Increased Mcl-1 expression has already been demonstrated for other malignancies, e.g. multiple myeloma and non-small cell lung cancer [17,18].
Positive_regulation (Increased) of Gene_expression (expression) of Mcl-1 in lung associated with lung cancer and multiple myeloma
10) Confidence 0.45 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.45 Pain Relevance 0
We have previously shown that Mcl-1 expression is considerably enhanced in human HCC tissue compared to adjacent non-tumor tissue [27].
Positive_regulation (enhanced) of Gene_expression (expression) of Mcl-1 associated with cancer and carcinoma
11) Confidence 0.45 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.51 Pain Relevance 0
RNA interference was performed by transfecting siRNA to specifically knock down Mcl-1 expression in HCC cells.
Positive_regulation (transfecting) of Gene_expression (expression) of Mcl-1 associated with targeted disruption and carcinoma
12) Confidence 0.45 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1601962 Disease Relevance 1.68 Pain Relevance 0
When compared to subjects without CAD, patients with CAD in both the non-high and high BMI groups had a median EAT thickness that was significantly increased (3.5 vs. 1.5 mm, p < 0.001 and 4.0 vs. 2.5 mm, p = 0.001, respectively, Figure 5).
Positive_regulation (increased) of Gene_expression (thickness) of EAT associated with coronary artery disease and obesity
13) Confidence 0.36 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 3.11 Pain Relevance 0
While EAT thickness was significantly increased in patients with MS and CAD regardless of BMI, the power of EAT to predict MS and CAD was stronger in patients with BMI < 27 kg/m2.
Positive_regulation (increased) of Gene_expression (thickness) of EAT associated with coronary artery disease, obesity and metabolic syndrome
14) Confidence 0.36 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 2.05 Pain Relevance 0.05
The median EAT thickness did not increase with an increase in the number of MS components (p = 0.121, Figure 3-B).
Neg (not) Positive_regulation (increase) of Gene_expression (thickness) of EAT associated with obesity and metabolic syndrome
15) Confidence 0.36 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2913996 Disease Relevance 2.87 Pain Relevance 0
Overexpression of p16 and Mcl-1 were observed in patients with longer survival outcomes (> 2 years).
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Mcl-1
16) Confidence 0.32 Published 2010 Journal World J Surg Oncol Section Abstract Doc Link PMC2913917 Disease Relevance 0.82 Pain Relevance 0
-induced Mcl-1 protein expression [46].
Positive_regulation (induced) of Gene_expression (expression) of Mcl-1
17) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.45 Pain Relevance 0.43
The induction of NOXA is therefore essential to override high Mcl-1 levels and allow for the activation of the apoptotic machinery in response to bortezomib.72 Also, NOXA’s interaction with anti-apoptotic members of the Bcl-2 family causes release of cytochrome c into the cytosol, leading to the activation of caspases and induction of apoptosis (Figure 8).73
Positive_regulation (high) of Gene_expression (levels) of Mcl-1 associated with apoptosis
18) Confidence 0.13 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.85 Pain Relevance 0
Biodiversity and TM
Positive_regulation (Biodiversity) of Gene_expression (Biodiversity) of TM
19) Confidence 0.07 Published 2007 Journal J Ethnobiol Ethnomedicine Section Body Doc Link PMC1847427 Disease Relevance 0.46 Pain Relevance 0

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