INT19806

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Context Info
Confidence 0.53
First Reported 1985
Last Reported 2011
Negated 3
Speculated 4
Reported most in Abstract
Documents 29
Total Number 35
Disease Relevance 14.17
Pain Relevance 6.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
signal transducer activity (Avp)
Anatomy Link Frequency
pituitary 4
brain 3
Leydig cells 2
uterine 2
hypothalamus 2
Avp (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 66 100.00 Very High Very High Very High
Opioid 39 100.00 Very High Very High Very High
narcan 28 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
Dopamine 2 100.00 Very High Very High Very High
Morphine 17 99.60 Very High Very High Very High
tolerance 7 99.32 Very High Very High Very High
medulla 40 98.96 Very High Very High Very High
agonist 38 98.94 Very High Very High Very High
Kinase C 24 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 335 99.78 Very High Very High Very High
Ebola Virus Infection 411 99.70 Very High Very High Very High
Nociception 8 99.32 Very High Very High Very High
Infection 252 98.32 Very High Very High Very High
Severe Combined Immunodeficiency 288 98.16 Very High Very High Very High
Ganglion Cysts 48 95.16 Very High Very High Very High
Anxiety Disorder 116 94.92 High High
Dysmenorrhea 4 93.44 High High
Hypoglycemia 16 91.52 High High
Death 106 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither the development of morphine tolerance nor the brain levels of arginine vasopressin were affected by exposure to forced swimming stress.
Neg (Neither) Regulation (affected) of vasopressin in brain associated with stress, tolerance and morphine
1) Confidence 0.53 Published 1990 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2095715 Disease Relevance 0.49 Pain Relevance 0.95
The mechanism(s) by which hypothalamic Avp and pituitary Avpr1b responsiveness is maintained during stress adaptation suggests the existence of numerous transcriptional and translational regulatory components involved in PVN and pituitary plasticity that dynamically alter Avp and Avpr1b levels according to demand (Volpi et al. 2004a,b).
Regulation (alter) of Avp in pituitary associated with stress
2) Confidence 0.49 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.77 Pain Relevance 0.06
Prodynorphin and vasopressin mRNA levels are differentially affected by chronic ethanol ingestion in the mouse.
Regulation (affected) of vasopressin associated with enkephalin
3) Confidence 0.49 Published 1993 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 8255170 Disease Relevance 0 Pain Relevance 0.20
Opioid peptides derived from the precursor, prodynorphin, are co-localized with vasopressin in the hypothalamus and posterior pituitary, and vasopressin and prodynorphin synthesis are coordinately regulated during salt-loading.
Regulation (regulated) of vasopressin in hypothalamus associated with opioid
4) Confidence 0.49 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255170 Disease Relevance 0 Pain Relevance 0.10
The effect of arginine vasopressin (AVP) on the gastrointestinal (GI) transit and its possible mechanism were studied using charcoal meal test in mice.
Spec (possible) Regulation (effect) of AVP
5) Confidence 0.45 Published 1993 Journal Life Sci. Section Abstract Doc Link 8103186 Disease Relevance 0 Pain Relevance 0
In this study, we identified polymorphisms in the Avp gene underlying a decreased expression of Avp mRNA in the hypothalamus of LAB animals under basal conditions compared to HAB, NAB and F1 mice, irrespective of gender.
Regulation (polymorphisms) of Avp in hypothalamus associated with anxiety disorder
6) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663030 Disease Relevance 0.39 Pain Relevance 0.07
The effects of intratesticular injection of naloxone, a universal opioid antagonist, on testicular immunoreactive (IR)-arginine vasopressin (AVP) content and on in vitro testosterone production by Leydig cells were investigated in the mouse.
Spec (investigated) Regulation (effects) of AVP in Leydig cells associated with antagonist, narcan and opioid
7) Confidence 0.44 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8485243 Disease Relevance 0 Pain Relevance 0.32
The effects of intratesticular injection of naloxone, a universal opioid antagonist, on testicular immunoreactive (IR)-arginine vasopressin (AVP) content and on in vitro testosterone production by Leydig cells were investigated in the mouse.
Spec (investigated) Regulation (effects) of arginine vasopressin in Leydig cells associated with antagonist, narcan and opioid
8) Confidence 0.44 Published 1993 Journal Biol. Reprod. Section Abstract Doc Link 8485243 Disease Relevance 0 Pain Relevance 0.32
The effect of arginine vasopressin (AVP) on the gastrointestinal (GI) transit and its possible mechanism were studied using charcoal meal test in mice.
Spec (possible) Regulation (effect) of vasopressin
9) Confidence 0.39 Published 1993 Journal Life Sci. Section Abstract Doc Link 8103186 Disease Relevance 0 Pain Relevance 0
The studies on the mechanism reveal that AVP acts without involving V1 and V2 vasopressin receptors.
Neg (without) Regulation (involving) of vasopressin
10) Confidence 0.39 Published 1993 Journal Life Sci. Section Abstract Doc Link 8103186 Disease Relevance 0 Pain Relevance 0.10
The AVP contents of the same brain areas, on the other hand, were not affected by acute morphine treatment.
Neg (not) Regulation (affected) of AVP in brain associated with morphine
11) Confidence 0.27 Published 1987 Journal Exp Brain Res Section Abstract Doc Link 3556459 Disease Relevance 0.07 Pain Relevance 0.86
Three analogues of posterior pituitary hormones, 1-deamino-2-D-Tyr(OEt)-4-Val-8-Orn-vasotocin(dE-VVT), 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-vasotocin(dE-TVT) and 1-deamino-2-D-Tyr(OEt)-oxytocin(dE-OXY) were compared for their inhibitory effects on vasopressin (VP)-induced uterine activity in healthy women.
Regulation (effects) of VP in uterine
12) Confidence 0.27 Published 1986 Journal Br J Obstet Gynaecol Section Abstract Doc Link 3942702 Disease Relevance 0.33 Pain Relevance 0.17
Three analogues of posterior pituitary hormones, 1-deamino-2-D-Tyr(OEt)-4-Val-8-Orn-vasotocin(dE-VVT), 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-vasotocin(dE-TVT) and 1-deamino-2-D-Tyr(OEt)-oxytocin(dE-OXY) were compared for their inhibitory effects on vasopressin (VP)-induced uterine activity in healthy women.
Regulation (effects) of vasopressin in uterine
13) Confidence 0.27 Published 1986 Journal Br J Obstet Gynaecol Section Abstract Doc Link 3942702 Disease Relevance 0.33 Pain Relevance 0.17
These results indicate that hypothalamic vasopressin and prodynorphin mRNA can be differentially regulated in certain situations.
Regulation (regulated) of vasopressin
14) Confidence 0.21 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255170 Disease Relevance 0 Pain Relevance 0
The apparent flip in control of ACTH release from Crh to Avp that is seen in some repeated stressors in rats (e.g. restraint) has made Avp and the Avpr1b attractive targets for pharmacological intervention in conditions of repeated or chronic stress, although it should be noted that Avp does not play a role in HPA axis responses to all chronic stressors (e.g. chronic morphine injection (Domokos et al. 2008)).
Regulation (targets) of Avp associated with stress and morphine
15) Confidence 0.19 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.79 Pain Relevance 0.12
Other peptide agonists selective for the rat Avpr1b have been generated by modifying positions 4 and 8 of the Avp analogue deamino-[Cys] arginine vasopressin (Pena et al. 2007a).
Regulation (modifying) of vasopressin associated with agonist
16) Confidence 0.19 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.31 Pain Relevance 0.33
Opioid peptides derived from the precursor, prodynorphin, are co-localized with vasopressin in the hypothalamus and posterior pituitary, and vasopressin and prodynorphin synthesis are coordinately regulated during salt-loading.
Regulation (regulated) of vasopressin in posterior pituitary associated with opioid
17) Confidence 0.16 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255170 Disease Relevance 0 Pain Relevance 0.10
Senescent change in tissue weight and immunoreactive beta-endorphin, enkephalin, and vasopressin in eight regions of C57BL/6J mouse brain and pituitary.
Regulation (change) of vasopressin in brain associated with enkephalin
18) Confidence 0.16 Published 1985 Journal Neurobiol. Aging Section Title Doc Link 3158833 Disease Relevance 0 Pain Relevance 0.55
Recent studies have also indicated that orofacial nociceptive information could be more highly modulated in Vp than in other trigeminal brainstem sensory nuclei [17,18] and so we have assayed the Vp in the current work.
Regulation (modulated) of Vp in brainstem associated with nociception and medulla
19) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.48 Pain Relevance 0.72
Astrocytic response to pIONL in Vp and Trigeminal root entry zone
Regulation (response) of Vp
20) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.10 Pain Relevance 0.43

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