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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a3) plasma membrane (Slc1a3)
Anatomy Link Frequency
neocortex 1
Slc1a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 88 100.00 Very High Very High Very High
Neuropathic pain 22 98.80 Very High Very High Very High
Spinal cord 37 98.00 Very High Very High Very High
cerebral cortex 2 95.84 Very High Very High Very High
Pain 22 85.36 High High
Glutamate receptor 8 77.04 Quite High
sodium channel 1 75.76 Quite High
allodynia 6 68.88 Quite High
Hyperalgesia 11 68.56 Quite High
Thermal hyperalgesia 1 67.88 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 38 98.80 Very High Very High Very High
Epilepsy 3 92.56 High High
Pain 22 85.36 High High
Nervous System Injury 10 70.48 Quite High
Hyperalgesia 12 68.56 Quite High
Anxiety Disorder 1 52.00 Quite High
INFLAMMATION 20 50.00 Quite Low
Nociception 18 37.52 Quite Low
Injury 2 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of glutamate uptake activity via GLAST and EAAC1 may contribute to the maintenance of neuropathic pain.
Negative_regulation (Reduction) of GLAST associated with glutamate and neuropathic pain
1) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 1.10 Pain Relevance 1.30
In the neocortex, GLT1 and GLAST inhibition increases extracellular glutamate, which affects the network excitability [33].
Negative_regulation (inhibition) of GLAST in neocortex associated with glutamate
2) Confidence 0.34 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.14 Pain Relevance 0.38

General Comments

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