INT198076

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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 2.41
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
neuronal 2
brain 2
pyramidal cells 1
nerve 1
cerebral cortex 1
Slc1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 553 100.00 Very High Very High Very High
Pyramidal cell 9 99.96 Very High Very High Very High
cerebral cortex 16 99.48 Very High Very High Very High
Hippocampus 44 87.92 High High
nMDA receptor 58 87.08 High High
excitatory amino acid 12 84.48 Quite High
long-term potentiation 13 74.56 Quite High
Glutamate receptor 40 74.24 Quite High
Somatosensory cortex 24 60.00 Quite High
Neurotransmitter 50 50.00 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 98 96.28 Very High Very High Very High
Anxiety Disorder 844 91.72 High High
Epilepsy 24 75.12 Quite High
Congenital Anomalies 28 26.12 Quite Low
Generalized Anxiety Disorder 8 17.92 Low Low
Obsessive-compulsive Disorder 48 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 48 5.00 Very Low Very Low Very Low
Cognitive Disorder 37 5.00 Very Low Very Low Very Low
Tourette's Syndrome 36 5.00 Very Low Very Low Very Low
Stress 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of particular interest, SLC1A1 is highly expressed in brain regions comprising CSTC circuits [87, 88].
Gene_expression (expressed) of SLC1A1 in brain
1) Confidence 0.73 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.45 Pain Relevance 0.11
In separate studies, we found that the levels of the SLC1A1 protein were increased in nerve ending particle (synaptosome) prepared from the brains of 12-mo-old Tg mice (1.39-fold) over those of wt mouse brain.
Gene_expression (levels) of SLC1A1 protein in nerve associated with targeted disruption
2) Confidence 0.72 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.17 Pain Relevance 0.50
This unaltered EAAC1 expression may be a reflection of its relative importance in glutamate clearance in the sensory cortex.
Gene_expression (expression) of EAAC1 in cortex associated with glutamate
3) Confidence 0.70 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.12 Pain Relevance 0.36
Injections of antisense oligonucleotides against the GLT1 and GLAST into the lateral ventricles of rats causes neurodegeneration in the cerebral cortex, but similar blockage of EAAC1 synthesis had only mild neurotoxic effects [5].
Gene_expression (synthesis) of EAAC1 in cerebral cortex associated with cerebral cortex
4) Confidence 0.70 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.14 Pain Relevance 0.40
The region 9p24 contains numerous predicted and known genes; however, of the known genes in this region at the time, SLC1A1 was the only one with expression in the brain according to Arnold et al. [83].
Gene_expression (expression) of SLC1A1 in brain
5) Confidence 0.63 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.47 Pain Relevance 0.14
SLC1A1/EAAC1
Gene_expression (/) of EAAC1
6) Confidence 0.63 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.46 Pain Relevance 0.20
SLC1A1/EAAC1
Gene_expression (/) of SLC1A1
7) Confidence 0.63 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.46 Pain Relevance 0.20
Here we now show, in vivo, that after 24 h of altered sensory stimulation, their expression increases, whereas the expression levels of the neuronal transporter EAAC1 remain unchanged.
Gene_expression (expression) of neuronal transporter EAAC1 in neuronal
8) Confidence 0.61 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.08 Pain Relevance 0.38
GLT1 and actin, or EAAC1 and actin (Figure 1) were first detected, followed by stripping of the membrane and reprobing for GLAST or tubulin, respectively.
Gene_expression (detected) of EAAC1
9) Confidence 0.61 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0 Pain Relevance 0
GLT1, GLAST, and EAAC1 levels were normalized to actin.


Gene_expression (levels) of EAAC1
10) Confidence 0.61 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0 Pain Relevance 0.05
In contrast, EAAC1 was found exclusively in neurons, mostly in the postsynaptic compartment, and sensory stimulation did not appear to alter this (Figure S1).


Gene_expression (found) of EAAC1 in neurons
11) Confidence 0.61 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0 Pain Relevance 0.04
This returns to basal levels 4 d after the stimulation was stopped, whereas the expression of the neuronal glutamate transporter EAAC1 remained unaltered throughout.
Gene_expression (expression) of EAAC1 in neuronal associated with glutamate
12) Confidence 0.54 Published 2006 Journal PLoS Biology Section Abstract Doc Link PMC1609127 Disease Relevance 0 Pain Relevance 0.30
And, on hippocampal CA1 pyramidal cells, EAAC1 slows the decay of NMDA currents, whereas GLT1 and GLAST having little effect [40].
Gene_expression (slows) of EAAC1 in pyramidal cells associated with pyramidal cell
13) Confidence 0.53 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.06 Pain Relevance 0.40

General Comments

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