INT198095

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.25
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PLA2G2A) extracellular region (PLA2G2A) endoplasmic reticulum (PLA2G2A)
Anatomy Link Frequency
brains 3
astrocyte 2
cerebellum 2
hippocampus 2
blood vessels 1
PLA2G2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 143 99.48 Very High Very High Very High
Inflammation 257 97.84 Very High Very High Very High
cytokine 82 97.32 Very High Very High Very High
ischemia 11 95.00 High High
Arthritis 11 79.32 Quite High
Inflammatory response 47 75.08 Quite High
Dismenorea 1 67.40 Quite High
Pyramidal cell 11 61.04 Quite High
Glutamate receptor 11 36.76 Quite Low
agonist 1 28.80 Quite Low
Disease Link Frequency Relevance Heat
Disease 694 98.92 Very High Very High Very High
INFLAMMATION 316 97.84 Very High Very High Very High
Injury 33 97.08 Very High Very High Very High
Amyloid Plaque 110 96.72 Very High Very High Very High
Cv General 4 Under Development 11 95.00 High High
Alzheimer's Dementia 55 93.92 High High
Brain Injury 11 89.60 High High
Sprains And Strains 11 87.40 High High
Targeted Disruption 13 84.32 Quite High
Cancer 11 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RT-PCR was carried out to assess sPLA2-IIA mRNA expression in astrocyte cultures.
Transcription (expression) of sPLA2 in astrocyte
1) Confidence 0.68 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.09 Pain Relevance 0.04
GSDM, LL and DGW acquired samples, performed all of the immunohistochemical studies and PCR analyses of sPLA2-IIA mRNA expression in human brains and cultured astrocytes, and edited the manuscript.
Transcription (expression) of sPLA2 in astrocytes
2) Confidence 0.68 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.72 Pain Relevance 0.13
Expression of sPLA2-IIA mRNA in hippocampus and cerebellum of AD and ND brains
Transcription (Expression) of sPLA2 in hippocampus associated with hippocampus and disease
3) Confidence 0.53 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.42 Pain Relevance 0.15
To demonstrate sPLA2-IIA mRNA expression in human brain, we measured levels of sPLA2-IIA mRNA by real time PCR analysis of RNA prepared from hippocampus and cerebellum samples from AD and ND patients.
Transcription (expression) of sPLA2 in hippocampus associated with hippocampus and disease
4) Confidence 0.53 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.49 Pain Relevance 0.16
to induce sPLA2-IIA mRNA expression, indicating that this gene is among those induced by inflammatory cytokines.
Transcription (expression) of sPLA2 associated with inflammation and cytokine
5) Confidence 0.53 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1613236 Disease Relevance 1.05 Pain Relevance 0.25
Immunoreactivity of sPLA2-IIA was also detected in GFAP-positive cells lining the blood vessels (Fig. 1D), and co-localized with amyloid deposits (Fig. 1E).
Transcription (detected) of sPLA2 in blood vessels associated with amyloid plaque
6) Confidence 0.53 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.86 Pain Relevance 0.09
On the other hand, there was no difference between sPLA2-IIA mRNA levels in cerebellar samples from AD and ND brains.


Transcription (levels) of sPLA2 in brains associated with disease
7) Confidence 0.53 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.66 Pain Relevance 0.13
In this report, we provide data demonstrating up-regulation of sPLA2-IIA mRNA and protein expression in reactive astrocytes in AD brains as compared to age-matched non-demented (ND) control brains.
Transcription (expression) of sPLA2 in brains associated with disease
8) Confidence 0.53 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 1.90 Pain Relevance 0.32
Stimulation of sPLA2-IIA mRNA expression in astrocytes from human post-mortem brains
Transcription (expression) of sPLA2 in brains
9) Confidence 0.53 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.82 Pain Relevance 0.13
synthase type 2/cyclooxygenase type 2 (COX-2) activity and the increased secretory phospholipase A2-IIA (sPLA2) mRNA, proteins and activities.
Transcription (activity) of sPLA2
10) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0.32 Pain Relevance 0.31
Expression of sPLA2-IIA mRNA in hippocampus and cerebellum of AD and ND brains
Transcription (Expression) of sPLA2 in cerebellum associated with hippocampus and disease
11) Confidence 0.18 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.42 Pain Relevance 0.15
To demonstrate sPLA2-IIA mRNA expression in human brain, we measured levels of sPLA2-IIA mRNA by real time PCR analysis of RNA prepared from hippocampus and cerebellum samples from AD and ND patients.
Transcription (expression) of sPLA2 in cerebellum associated with hippocampus and disease
12) Confidence 0.18 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.49 Pain Relevance 0.16

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