INT1981

Context Info Confidence 0.47 First Reported 1979 Last Reported 2010 Negated 4 Speculated 0 Reported most in Body Documents 219 Total Number 249 Disease Relevance 223.48 Pain Relevance 16.41

Anatomy Link Frequency eyes 25 outflow 8 anterior chamber 3 superior 3 14.1 2 NARFL (Homo sapiens)

Pain Link Frequency Relevance Heat beta blocker 578 99.98 Serotonin 156 99.98 lidocaine 27 99.92 Clonidine 44 99.82 Pain 204 99.52 antagonist 339 99.46 anesthesia 252 99.44 agonist 441 99.14 Inflammation 591 98.24 Onset of action 22 96.64

Disease Link Frequency Relevance Heat Ocular Hypertension 22633 100.00 Glaucoma 6806 99.84 Cataract 638 99.60 Uveitis 732 99.56 Pain 198 99.52 Open-angle Glaucoma 471 99.48 Low Tension Glaucoma 440 99.48 Hypotension 1230 99.40 Pressure And Volume Under Development 291 98.30 INFLAMMATION 628 98.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pars plana vitrectomy aims to decrease the IOP by removing intravitreal triamcinolone crystals, but it is a very aggressive way to reduce the IOP; therefore, the method should be limited to eyes that would receive additional benefit from this surgery.

Negative_regulation (reduce) of IOP in eyes associated with ocular hypertension

1) Confidence 0.47 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.15 Pain Relevance 0

In 40 eyes (27.2%), topical treatment was initiated to reduce the IOP when persistent elevation above 25 mm Hg was observed over one month in weekly examinations after the first observation of IOP ?

Negative_regulation (reduce) of IOP in eyes associated with ocular hypertension

2) Confidence 0.47 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.39 Pain Relevance 0

Cyclophotocoagulation is another technique we used to reduce the IOP because it is easy to perform and has fewer complications than the aforementioned surgeries.

Negative_regulation (reduce) of IOP associated with ocular hypertension

3) Confidence 0.47 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.15 Pain Relevance 0

Also the reduction in IOP with the combination was numerically greater than for either active component and statically significant at most of the time points and visits.

Negative_regulation (reduction) of IOP associated with ocular hypertension

4) Confidence 0.46 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698680 Disease Relevance 0.53 Pain Relevance 0

They reduce IOP by inhibiting aqueous humour production (Coakes and Brubaker 1978).

Negative_regulation (reduce) of IOP in aqueous humour associated with ocular hypertension

5) Confidence 0.46 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698680 Disease Relevance 1.04 Pain Relevance 0.13

The reduction of IOP by prostaglandin analogues is based on an increase in trabecular and uveoscleral outflow (Mishima et al 1977).

Negative_regulation (reduction) of IOP in outflow associated with ocular hypertension

6) Confidence 0.46 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698680 Disease Relevance 1.39 Pain Relevance 0

Supine 2 IOP (31 +/- 2 mmHg) decreased in comparison with prone 2 IOP (P < 0.05) but was relatively elevated in comparison with supine 1 and baseline (P < 0.05).

Negative_regulation (decreased) of IOP

7) Confidence 0.37 Published 2001 Journal Anesthesiology Section Body Doc Link 11748391 Disease Relevance 0.05 Pain Relevance 0

Pars plana vitrectomy aims to decrease the IOP by removing intravitreal triamcinolone crystals, but it is a very aggressive way to reduce the IOP; therefore, the method should be limited to eyes that would receive additional benefit from this surgery.

Negative_regulation (decrease) of IOP in eyes associated with ocular hypertension

8) Confidence 0.35 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.15 Pain Relevance 0

However, in a small percentage of eyes the hypertension may be uncontrollable with topical treatment; in such cases, surgical procedures to reduce the IOP should be carried out (Jonas 2005; Jonas et al 2005).

Negative_regulation (reduce) of IOP in eyes associated with pressure and volume under development and ocular hypertension

9) Confidence 0.35 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.05 Pain Relevance 0.04

Success of IOP control was defined as IOP < 22 mmHg or a decrease in IOP of > 30%; preservation of visual acuity or control of pain in blind eyes was also assessed.

Negative_regulation (decrease) of IOP in eyes

10) Confidence 0.35 Published 1998 Journal Aust N Z J Ophthalmol Section Body Doc Link 9630294 Disease Relevance 0 Pain Relevance 0

For the half-treatment cases (group B). the mean pre-operative and postoperative IOP was 29.4 +/- 4.3 and 18.9 +/- 5.7 mmHg, respectively (a 36% reduction); 63% of patients achieved IOP < 22 mmHg and 50% gained an IOP reduction of > 30%.

Negative_regulation (reduction) of IOP

11) Confidence 0.35 Published 1998 Journal Aust N Z J Ophthalmol Section Body Doc Link 9630294 Disease Relevance 0 Pain Relevance 0

For the full treatment cases (group A), mean (+/-SD) pre-operative and postoperative IOP was 49.4 +/- 11.2 and 25.8 +/- 17.7 mmHg, respectively (a 48% reduction); 55% of patients achieved IOP < 22 mmHg and 68% gained an IOP reduction of > 30%.

Negative_regulation (reduction) of IOP

12) Confidence 0.35 Published 1998 Journal Aust N Z J Ophthalmol Section Body Doc Link 9630294 Disease Relevance 0 Pain Relevance 0

In one eye, cyclophotocoagulation was repeated 1 month after the first procedure because of an inadequate reduction in IOP.

Negative_regulation (reduction) of IOP in eye associated with ocular hypertension

13) Confidence 0.35 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.27 Pain Relevance 0.03

In 40 (27.7%) eyes, topical antiglaucomatous therapy was needed and 7 later required surgical intervention to lower the IOP.

Negative_regulation (lower) of IOP in eyes associated with ocular hypertension

14) Confidence 0.35 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2698684 Disease Relevance 0.77 Pain Relevance 0

In our series, the rates of topical treatment and surgery for reducing high IOP were 27% and 4.7%, respectively.

Negative_regulation (reducing) of IOP associated with ocular hypertension

15) Confidence 0.35 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698684 Disease Relevance 1.14 Pain Relevance 0

A more pronounced decrease in IOP after the first route of administration became evident.

Negative_regulation (decrease) of IOP associated with ocular hypertension

16) Confidence 0.35 Published 1979 Journal Albrecht Von Graefes Arch Klin Exp Ophthalmol Section Abstract Doc Link 312040 Disease Relevance 0.49 Pain Relevance 0.46

IOP decreased significantly (p less than 0.01) after induction of anesthesia with thiopentone in all the groups.

Negative_regulation (decreased) of IOP associated with anesthesia and ocular hypertension

17) Confidence 0.35 Published 1992 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 1632179 Disease Relevance 0.70 Pain Relevance 0.54

On the other hand, a slight decrease in IOP was observed by similar treatment of prazosin and yohimbine.

Negative_regulation (decrease) of IOP associated with ocular hypertension

18) Confidence 0.35 Published 1992 Journal Nippon Ganka Gakkai Zasshi Section Abstract Doc Link 1348394 Disease Relevance 1.00 Pain Relevance 0.40

The IOP of both eyes was decreased in a dose-related fashion by i.c.v. administration of clonidine or guanfacine.

Negative_regulation (decreased) of IOP in eyes associated with ocular hypertension and clonidine

19) Confidence 0.35 Published 1992 Journal Nippon Ganka Gakkai Zasshi Section Abstract Doc Link 1348394 Disease Relevance 1.07 Pain Relevance 0.57

On the contrary, unilateral topical administration of clonidine or guanfacine decreased the IOP of both eyes.

Negative_regulation (decreased) of IOP in eyes associated with ocular hypertension and clonidine

20) Confidence 0.35 Published 1992 Journal Nippon Ganka Gakkai Zasshi Section Abstract Doc Link 1348394 Disease Relevance 1.08 Pain Relevance 0.54

General Comments

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