INT198119

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.42
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Aqp9)
Anatomy Link Frequency
ductules 6
epididymis 2
astrocytes 2
Aqp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 4 99.48 Very High Very High Very High
hyperexcitability 1 6.80 Low Low
ketamine 14 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Analgesic 7 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 1 99.48 Very High Very High Very High
Hypoxia 5 98.72 Very High Very High Very High
Injury 17 95.44 Very High Very High Very High
Targeted Disruption 28 77.84 Quite High
Congenital Anomalies 8 74.80 Quite High
Gliosis 2 74.80 Quite High
Ocular Hypertension 5 61.36 Quite High
Glaucoma 11 49.52 Quite Low
Stress 4 42.28 Quite Low
Middle Cerebral Artery Infarction 2 41.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, both estradiol and dihydrotestosterone (DHT) restored AQP9 expression in the efferent ductules, but in the initial segment epididymis, only DHT restored AQP9 to normal levels [16].
Positive_regulation (ductules) of Gene_expression (expression) of AQP9 in epididymis
1) Confidence 0.50 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Data presented here support the hypothesis that DHT regulation of AQP9 expression in efferent ductules is likely to be mediated by its reduction to 3?
Positive_regulation (ductules) of Gene_expression (expression) of AQP9 in ductules
2) Confidence 0.50 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.07 Pain Relevance 0
If DHT was acting directly through its high affinity binding to AR, then testosterone alone should also have modulated AQP9 expression.
Positive_regulation (modulated) of Gene_expression (expression) of AQP9
3) Confidence 0.50 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
-diol could be the alternative modulator of AQP9 expression even during the pre-pubertal period.
Positive_regulation (modulator) of Gene_expression (expression) of AQP9
4) Confidence 0.50 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.31 Pain Relevance 0
Data show that, after castration, AQP9 expression was significantly reduced in the efferent ductules. 3-beta-diol injections restored AQP9 expression, similar to DHT and estradiol.
Positive_regulation (restored) of Gene_expression (expression) of AQP9 in ductules
5) Confidence 0.46 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Data show that, after castration, AQP9 expression was significantly reduced in the efferent ductules. 3-beta-diol injections restored AQP9 expression, similar to DHT and estradiol.
Positive_regulation (restored) of Gene_expression (expression) of AQP9 in ductules
6) Confidence 0.46 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
g) AQP9 expression in developing rats progressively increases and reaches adult levels by 4 weeks post-natal [9].
Positive_regulation (increases) of Gene_expression (expression) of AQP9
7) Confidence 0.43 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.34 Pain Relevance 0
While AQP9 expression was upregulated after an ischemic insult [67], hypoxia evoked a significant decrease in AQP9 in astrocytes [66].
Positive_regulation (upregulated) of Gene_expression (expression) of AQP9 in astrocytes associated with hypoxia
8) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.69 Pain Relevance 0.05

General Comments

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