INT198121

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Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 27
Disease Relevance 5.67
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Aqp9)
Anatomy Link Frequency
ductules 7
amacrine cells 2
retina 1
epithelium 1
B cell 1
Aqp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 36 99.48 Very High Very High Very High
hyperexcitability 9 47.68 Quite Low
potassium channel 9 46.24 Quite Low
ketamine 36 15.76 Low Low
anesthesia 27 5.00 Very Low Very Low Very Low
Analgesic 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
B-cell Lymphoma 18 100.00 Very High Very High Very High
Cv General 4 Under Development 9 99.48 Very High Very High Very High
Injury 153 99.16 Very High Very High Very High
Disorders Of The Lacrimal System 9 99.08 Very High Very High Very High
Death 18 99.00 Very High Very High Very High
Ganglion Cysts 81 98.78 Very High Very High Very High
Hypoxia 45 98.08 Very High Very High Very High
Ocular Hypertension 45 96.64 Very High Very High Very High
Disease 18 93.52 High High
Cv Unclassified Under Development 18 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data presented here support the hypothesis that DHT regulation of AQP9 expression in efferent ductules is likely to be mediated by its reduction to 3?
Gene_expression (expression) of AQP9 in ductules
1) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.07 Pain Relevance 0
In control rats, AQP9 was expressed in efferent ductule epithelium, but restricted to the microvillus border of non-ciliated cells (Fig. 3).
Gene_expression (expressed) of AQP9 in epithelium
2) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.07 Pain Relevance 0
AQP9 expression
Gene_expression (expression) of AQP9
3) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.08 Pain Relevance 0
However, both estradiol and dihydrotestosterone (DHT) restored AQP9 expression in the efferent ductules, but in the initial segment epididymis, only DHT restored AQP9 to normal levels [16].
Gene_expression (expression) of AQP9 in epididymis
4) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Bilateral surgical castration significantly reduced the AQP9 expression by 20% compared with sham-operated controls, as determined by image analysis.
Gene_expression (expression) of AQP9
5) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.06 Pain Relevance 0
-diol could be the alternative modulator of AQP9 expression even during the pre-pubertal period.
Gene_expression (expression) of AQP9
6) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.26 Pain Relevance 0
If DHT was acting directly through its high affinity binding to AR, then testosterone alone should also have modulated AQP9 expression.
Gene_expression (expression) of AQP9
7) Confidence 0.77 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
AQP9 has been detected in tyrosine hydroxylase-expressing amacrine cells in the rat retina [25], rat retinal ganglion cells (RGCs) [26], and human and rat pigment epithelial retinal cells [27].
Gene_expression (detected) of AQP9 in retinal ganglion cells associated with ganglion cysts
8) Confidence 0.72 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.71 Pain Relevance 0.04
g) AQP9 expression in developing rats progressively increases and reaches adult levels by 4 weeks post-natal [9].
Gene_expression (expression) of AQP9
9) Confidence 0.67 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.33 Pain Relevance 0
Epithelial ciliated cells, as well as the peritubular cells and components of the intertubular tissue were negative for AQP9.
Neg (negative) Gene_expression (negative) of AQP9 in ciliated cells
10) Confidence 0.67 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.07 Pain Relevance 0
AQP9 possesses general features of a water channel, but in addition it is permeable to a wide variety of noncharged solutes, such as lactate, ?
Gene_expression (possesses) of AQP9
11) Confidence 0.62 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.70 Pain Relevance 0.03
Effects of 3-beta-diol, an androgen metabolite with intrinsic estrogen-like effects, in modulating the aquaporin-9 expression in the rat efferent ductules

Background

Gene_expression (expression) of aquaporin-9 in ductules
12) Confidence 0.60 Published 2006 Journal Reprod Biol Endocrinol Section Title Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
-diol, in the regulation of AQP9 expression in adult rat efferent ductules.
Gene_expression (expression) of AQP9 in ductules
13) Confidence 0.60 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Changes in AQP9 expression in the efferent ductules were investigated by using immunohistochemistry and Western blotting assay.


Gene_expression (expression) of AQP9 in ductules
14) Confidence 0.60 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Treatment related effects in body and organ weights, as well as hormone levels and immunoquantification of AQP9 expression, were analyzed statistically using multiple variance analyses (ANOVA).
Gene_expression (expression) of AQP9 in body
15) Confidence 0.60 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Data show that, after castration, AQP9 expression was significantly reduced in the efferent ductules. 3-beta-diol injections restored AQP9 expression, similar to DHT and estradiol.
Gene_expression (expression) of AQP9 in ductules
16) Confidence 0.60 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Data show that, after castration, AQP9 expression was significantly reduced in the efferent ductules. 3-beta-diol injections restored AQP9 expression, similar to DHT and estradiol.
Gene_expression (expression) of AQP9 in ductules
17) Confidence 0.60 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Comparatively the AQP9 expression was decreased after castration (60%) and greatly recovered after estradiol (70% increase), DHT (52% increase) and 3?
Gene_expression (expression) of AQP9
18) Confidence 0.60 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
-diol was performed to investigate the regulation of AQP9 expression in rat efferent ductules.
Gene_expression (expression) of AQP9 in ductules
19) Confidence 0.60 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Thus, it is unlikely that DHT resupplementation after castration was able to directly restore the AQP9 staining.
Gene_expression (staining) of AQP9
20) Confidence 0.58 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0

General Comments

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