INT198123

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 0.55
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Aqp9)
Anatomy Link Frequency
ductules 10
amacrine cells 1
retinal ganglion cell 1
Aqp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 12 15.76 Low Low
anesthesia 7 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
hyperexcitability 1 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 98.00 Very High Very High Very High
Death 2 97.44 Very High Very High Very High
Injury 17 93.92 High High
Apoptosis 3 84.36 Quite High
Targeted Disruption 24 75.16 Quite High
B-cell Lymphoma 2 47.08 Quite Low
Body Weight 24 28.88 Quite Low
Congenital Anomalies 7 25.52 Quite Low
Disease 2 25.00 Low Low
Glaucoma 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data presented here support the hypothesis that DHT regulation of AQP9 expression in efferent ductules is likely to be mediated by its reduction to 3?
Regulation (regulation) of Gene_expression (expression) of AQP9 in ductules
1) Confidence 0.61 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.08 Pain Relevance 0
-diol was performed to investigate the regulation of AQP9 expression in rat efferent ductules.
Spec (investigate) Regulation (regulation) of Gene_expression (expression) of AQP9 in ductules
2) Confidence 0.27 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Effects of 3-beta-diol, an androgen metabolite with intrinsic estrogen-like effects, in modulating the aquaporin-9 expression in the rat efferent ductules

Background

Regulation (modulating) of Gene_expression (expression) of aquaporin-9 in ductules
3) Confidence 0.27 Published 2006 Journal Reprod Biol Endocrinol Section Title Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
If DHT was acting directly through its high affinity binding to AR, then testosterone alone should also have modulated AQP9 expression.
Regulation (modulated) of Gene_expression (expression) of AQP9
4) Confidence 0.27 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Changes in AQP9 expression in the efferent ductules were investigated by using immunohistochemistry and Western blotting assay.


Spec (investigated) Regulation (Changes) of Gene_expression (expression) of AQP9 in ductules
5) Confidence 0.27 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
-diol, in the regulation of AQP9 expression in adult rat efferent ductules.
Regulation (regulation) of Gene_expression (expression) of AQP9 in ductules
6) Confidence 0.27 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Changes in AQP9 expression suggest a contribution of the channel to retinal ganglion cell death and response of distinct amacrine cells known to express AQP9 following traumatic injuries.



Regulation (Changes) of in retinal ganglion cell Gene_expression (expression) of AQP9 in amacrine cells associated with ganglion cysts, injury and death
7) Confidence 0.25 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2831780 Disease Relevance 0.47 Pain Relevance 0

General Comments

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