INT198124

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 3.62
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Aqp9)
Anatomy Link Frequency
retinas 1
B cell 1
male reproductive tract 1
epididymis 1
optic nerve 1
Aqp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 24 82.20 Quite High
potassium channel 6 60.96 Quite High
hyperexcitability 6 37.84 Quite Low
ketamine 12 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
B-cell Lymphoma 12 99.60 Very High Very High Very High
Injury 102 97.24 Very High Very High Very High
Hypoxia 30 95.20 Very High Very High Very High
Targeted Disruption 24 95.20 Very High Very High Very High
Glaucoma 66 94.00 High High
Optic Nerve Injuries 42 92.56 High High
Ganglion Cysts 54 91.96 High High
Stress 24 91.20 High High
Neuropathic Pain 6 88.68 High High
Ocular Hypertension 30 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results confirm our previous investigation of AQP9 regulation [16], but add to the growing body of data supporting a steroid hormonal role for 3?
Spec (investigation) Regulation (regulation) of AQP9 in body
1) Confidence 0.61 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Effect of optic nerve crush on AQP9 in rat retinas
Regulation (Effect) of AQP9 in retinas
2) Confidence 0.57 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.18 Pain Relevance 0.03
In the current study we analyzed changes in AQP4 and AQP9 following optic nerve crush (ONC).
Regulation (changes) of AQP9 in optic nerve
3) Confidence 0.57 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 1.20 Pain Relevance 0.04
These data are in agreement with those of Badran and Hermo (2002), who concluded that a luminal factor coming from the testis, but not testosterone per si, was involved in the modulation of AQP9 in the initial segment epididymis.
Regulation (modulation) of AQP9 in epididymis
4) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.21 Pain Relevance 0
It is also relevant that female tissues show a similar regulation of AQP9 by androgen metabolites, such as estradiol [50].
Regulation (regulation) of AQP9
5) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.09 Pain Relevance 0
resulted in a small reduction of AQP9 in the male tract [17], providing further support for the participation of another testosterone metabolite in the regulation of AQP9.
Regulation (regulation) of AQP9
6) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.09 Pain Relevance 0
Taken together, these data indicate that the underlying mechanisms for AQP9 regulation are complex and likely involve multiple androgen metabolites.


Regulation (regulation) of AQP9
7) Confidence 0.45 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0.09 Pain Relevance 0
ONC exerted novel changes in AQP9 mRNA and protein levels where it appears that increased mRNA slowed protein translation, and whenever mRNA decreased, protein production increased.
Regulation (changes) of AQP9
8) Confidence 0.42 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.59 Pain Relevance 0.03
The differential regulation of AQP9 in the male tract, depending on the steroid hormone and location in the male reproductive tract, suggested that the selective presence of estrogen receptors (ER?
Regulation (regulation) of AQP9 in male reproductive tract
9) Confidence 0.27 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1615873 Disease Relevance 0 Pain Relevance 0
Real-time PCR was used to measure changes in AQP4, AQP9, thy-1, Kir4.1 (K+ channel), and ?
Regulation (changes) of AQP9
10) Confidence 0.25 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2831780 Disease Relevance 0.45 Pain Relevance 0
Changes in AQP4, AQP9, Kir4.1, B cell lymphoma-x (bcl-xl), and glial fibrillary acidic protein (GFAP) expression were measured in total retinal extracts using western blotting.


Regulation (Changes) of AQP9 in B cell associated with b-cell lymphoma
11) Confidence 0.25 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2831780 Disease Relevance 0.44 Pain Relevance 0
ONC resulted in novel changes in AQP9; its mRNA increased at days 2 and 14 (150±30% and 200±30%, respectively, p<0.001 versus control, Figure 4B, n=5) but decreased at day 7 (44±13%, p<0.001 versus sham, Figure 4B, n=6).
Regulation (changes) of AQP9
12) Confidence 0.22 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.29 Pain Relevance 0

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