INT198136

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.72
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (BCL2A1)
Anatomy Link Frequency
amygdala 1
insula 1
cortex 1
BCL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
insula 36 100.00 Very High Very High Very High
Anterior cingulate cortex 29 100.00 Very High Very High Very High
Somatosensory cortex 16 100.00 Very High Very High Very High
primary somatosensory cortex 8 100.00 Very High Very High Very High
reflex sympathetic dystrophy 14 98.68 Very High Very High Very High
amygdala 139 97.82 Very High Very High Very High
Hyperalgesia 2 97.52 Very High Very High Very High
cva 8 95.48 Very High Very High Very High
positron emission tomography 4 91.76 High High
Lasting pain 90 90.68 High High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 14 98.68 Very High Very High Very High
Anxiety Disorder 99 98.52 Very High Very High Very High
Hyperalgesia 2 97.52 Very High Very High Very High
Post-traumatic Stress Disorder 166 95.50 Very High Very High Very High
Cv General 3 Under Development 8 95.48 Very High Very High Very High
Acute Coronary Syndrome 20 91.64 High High
Somatoform Disorder 6 91.04 High High
Myocardial Infarction 30 88.88 High High
Death 16 88.64 High High
Low Back Pain 14 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also failed to demonstrate enhanced ACC activation in the empathy condition in our sample despite the fact that we observed a positive correlation of activation in ACC and individual differences in unpleasantness ratings.
Positive_regulation (activation) of ACC
1) Confidence 0.67 Published 2008 Journal Emotion Section Body Doc Link PMC2672051 Disease Relevance 0.20 Pain Relevance 0.23
This lack of increased ACC activation on a group level during the empathy condition parallels the findings of the Singer et al. (2006) study, which also only found reliable activation in ACC for the female participants (see also Singer et al., 2004), not for the male participants.
Positive_regulation (activation) of ACC
2) Confidence 0.67 Published 2008 Journal Emotion Section Body Doc Link PMC2672051 Disease Relevance 0.15 Pain Relevance 0.15
PET studies of patients with PTSD show decreased anterior cingulate cortex (ACC, part of the PFC) activation to the emotional Stroop using fear-evoking words, such as “rape”;41 however, PTSD patients have normal mPFC activation to nonemotional interference tasks.41,42 Weakened mPFC control of the amygdala may be a risk factor for psychopathology: a recent study of children with depressed parents found a lack of ACC activation to the emotional Stroop, using both fear-relevant words depicting physical threat and social threat.43
Positive_regulation (activation) of ACC in amygdala associated with post-traumatic stress disorder, anxiety disorder, positron emission tomography, amygdala and anterior cingulate cortex
3) Confidence 0.67 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938301 Disease Relevance 1.12 Pain Relevance 0.58
Notwithstanding the fragility of the above evidence in its favor, the recently updated ACC/AHA Guidelines now call strongly (Class I, Level of Evidence A) for an early invasive strategy in patients with unstable angina/NSTEMI who have any 'high-risk indicators' [57].
Positive_regulation (updated) of ACC associated with cva
4) Confidence 0.49 Published 2006 Journal BMC Med Section Body Doc Link PMC1617111 Disease Relevance 0.88 Pain Relevance 0.13
Maihöfner et al. [26] observed activations in the S1 and S2 cortex, insula, PFC, and in the ACC during pin-prick stimulation of CRPS patients who experience hyperalgesia.
Positive_regulation (activations) of ACC in insula associated with somatosensory cortex, hyperalgesia, primary somatosensory cortex, reflex sympathetic dystrophy, insula and anterior cingulate cortex
5) Confidence 0.49 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.54 Pain Relevance 1.98
Once activated, AMPK phosphorylates acetyl-CoA carboxylase (ACC) and switches on energy-producing pathways at the expense of energy-depleting processes [10]–[12].
Positive_regulation (activated) of ACC
6) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.28 Pain Relevance 0
Maihöfner et al. [26] observed activations in the S1 and S2 cortex, insula, PFC, and in the ACC during pin-prick stimulation of CRPS patients who experience hyperalgesia.
Positive_regulation (activations) of ACC in cortex associated with somatosensory cortex, hyperalgesia, primary somatosensory cortex, reflex sympathetic dystrophy, insula and anterior cingulate cortex
7) Confidence 0.17 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.54 Pain Relevance 1.98

General Comments

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