INT19819

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Context Info
Confidence 0.05
First Reported 1986
Last Reported 1990
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk, Ins1) extracellular space (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
islets of Langerhans 2
Penk (Rattus norvegicus)
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
narcan 5 99.42 Very High Very High Very High
antagonist 1 99.24 Very High Very High Very High
opiate 1 98.84 Very High Very High Very High
Neurotransmitter 4 69.52 Quite High
Somatostatin 1 43.72 Quite Low
Endogenous opioid 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The addition of the specific opiate receptor antagonist naloxone (10(-5)M) did not block the effect of leu-enkephalin in the presence of insulin.
leu-enkephalin Regulation (effect) of Gene_expression (presence) of insulin associated with antagonist, narcan, enkephalin and opiate
1) Confidence 0.05 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3513044 Disease Relevance 0 Pain Relevance 0.79
The effects of the opioid peptides Met- and Leu-enkephalin on the expression of the insulin gene in isolated adult rat islets of Langerhans were examined.
Leu-enkephalin Spec (examined) Regulation (effects) of Gene_expression (expression) of insulin in islets of Langerhans associated with enkephalin and opioid
2) Confidence 0.05 Published 1990 Journal Biomed. Biochim. Acta Section Abstract Doc Link 2097989 Disease Relevance 0 Pain Relevance 0.48

General Comments

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