INT19823

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Context Info
Confidence 0.36
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.37
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
spinal 1
Pbrgcsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 2 97.46 Very High Very High Very High
Angina 1 96.32 Very High Very High Very High
lidocaine 2 95.44 Very High Very High Very High
chemokine 25 95.36 Very High Very High Very High
cytokine 79 92.64 High High
postherpetic neuralgia 1 91.16 High High
Inflammatory mediators 8 90.08 High High
opioid receptor 1 89.72 High High
Endogenous opioid 1 87.92 High High
intrathecal 1 85.36 High High
Disease Link Frequency Relevance Heat
Neutropenia 24 99.84 Very High Very High Very High
Stress 12 99.40 Very High Very High Very High
Increased Venous Pressure Under Development 3 99.00 Very High Very High Very High
Infection 159 98.96 Very High Very High Very High
Syncope 1 98.48 Very High Very High Very High
Anaphylaxis 1 98.12 Very High Very High Very High
Vomiting 11 96.64 Very High Very High Very High
Angina 1 96.32 Very High Very High Very High
Dyspnea 2 95.84 Very High Very High Very High
Stomatitis 20 94.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Individual timing of blood counts in G-CSF prophylaxis after myelosuppressive chemotherapy reduces G-CSF injections, blood counts, and costs: a prospective randomized study in children and adolescents.
Negative_regulation (reduces) of G-CSF in blood
1) Confidence 0.36 Published 2002 Journal Support Care Cancer Section Title Doc Link 12436219 Disease Relevance 0.57 Pain Relevance 0.08
The number of days in hospital was reduced significantly in the G-CSF group (P = 0.02).
Negative_regulation (reduced) of G-CSF
2) Confidence 0.36 Published 1998 Journal Bone Marrow Transplant. Section Abstract Doc Link 9827976 Disease Relevance 0.58 Pain Relevance 0.10
These reactions led to discontinuation of G-CSF in the majority of patients.
Negative_regulation (discontinuation) of G-CSF
3) Confidence 0.34 Published 2000 Journal Bone Marrow Transplant. Section Abstract Doc Link 10849533 Disease Relevance 0.75 Pain Relevance 0.10
Importantly, we observed a significant azithromycin-dependent decrease in G-CSF and decreased concentrations, albeit not statistically significant, of CCL2/JE, CCL3/MIP-1?
Negative_regulation (decrease) of G-CSF
4) Confidence 0.27 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 0.63 Pain Relevance 0.33
and G-CSF were significantly attenuated in the SC-560 and celecoxib treated groups versus control.
Negative_regulation (attenuated) of G-CSF
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 0.32 Pain Relevance 0.23
and G-CSF were significantly attenuated in the SC-560 and celecoxib groups versus control and IL-6 levels were significantly lower in BAL fluid of celecoxib treated mice versus control and versus the SC-560 group.
Negative_regulation (attenuated) of G-CSF
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2904706 Disease Relevance 1.34 Pain Relevance 0.17
An interesting observation was that treatment with either COX inhibitor led to depressed levels of G-CSF in BAL fluid on day 4 of infection and a similar trend was observed in serum.
Negative_regulation (levels) of G-CSF associated with infection
7) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 1.09 Pain Relevance 0
Nevertheless, the observation that COX inhibitors can depress G-CSF levels during stress granulopoiesis is important and may have significant consequences in other infectious models/states.
Negative_regulation (depress) of G-CSF associated with stress
8) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 0.83 Pain Relevance 0.27
Tyr-MIF, an opioid tetrapeptide (H-Tyr-Pro-Leu-Gly-NH2), demonstrated a dose-dependent inhibition of colony formation at concentrations < 10 uM, inhibiting M-CSF and G-CSF-responsive progenitor cells equally.
Negative_regulation (inhibiting) of G-CSF associated with opioid
9) Confidence 0.04 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 12013510 Disease Relevance 0 Pain Relevance 0.31
Mitchell et al[5] studied 112 patients in the first randomization for the effect of G-CSF in FN.
Negative_regulation (effect) of G-CSF associated with neutropenia
10) Confidence 0.02 Published 2005 Journal BMC Med Res Methodol Section Body Doc Link PMC1145185 Disease Relevance 0.46 Pain Relevance 0
Most patients could receive PLD continually by concomitant use of G-CSF and dose modification, such as dose reduction and delay of next administration.
Negative_regulation (reduction) of G-CSF
11) Confidence 0.01 Published 2008 Journal Japanese Journal of Clinical Oncology Section Body Doc Link PMC2572298 Disease Relevance 0.72 Pain Relevance 0
The auditory brain stem response (ABR) during high spinal block with intact consciousness was not depressed in its wave height.
Neg (not) Negative_regulation (depressed) of auditory brain stem response in spinal
12) Confidence 0.01 Published 1990 Journal Masui Section Abstract Doc Link 2098601 Disease Relevance 0.09 Pain Relevance 0.54

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