INT1983

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Context Info
Confidence 0.58
First Reported 1978
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 10
Disease Relevance 4.44
Pain Relevance 4.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cbr1) plasma membrane (Cbr1) nucleus (Cbr1)
cytoplasm (Cbr1)
Anatomy Link Frequency
brain 2
macrophages 1
Cbr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 3 99.80 Very High Very High Very High
Analgesic 14 99.58 Very High Very High Very High
Paracetamol 17 99.08 Very High Very High Very High
agonist 1 98.08 Very High Very High Very High
cytokine 15 97.92 Very High Very High Very High
Hyperalgesia 3 96.56 Very High Very High Very High
Central nervous system 1 95.68 Very High Very High Very High
aspirin 23 94.04 High High
Pain 15 93.44 High High
Inflammation 121 91.28 High High
Disease Link Frequency Relevance Heat
Stress 270 99.16 Very High Very High Very High
Apoptosis 170 98.68 Very High Very High Very High
Death 45 97.24 Very High Very High Very High
Hyperalgesia 3 96.56 Very High Very High Very High
Pain 8 93.44 High High
INFLAMMATION 121 91.28 High High
Pleurisy 1 87.72 High High
Crystal Associated Disease 1 82.72 Quite High
Arthritis 1 82.16 Quite High
Nociception 7 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selected compounds were tested for their ability to produce gastric damage in fasted mice and for inhibition of prostaglandin synthetase activity in vitro.
Negative_regulation (inhibition) of prostaglandin synthetase
1) Confidence 0.58 Published 1986 Journal J. Med. Chem. Section Abstract Doc Link 3086559 Disease Relevance 0 Pain Relevance 0.25
Also, acetaminophen (APAP) is effective analgesics and may selectively inhibit brain prostaglandin synthetase.
Spec (may) Negative_regulation (inhibit) of prostaglandin synthetase in brain associated with paracetamol and analgesic
2) Confidence 0.31 Published 2001 Journal Brain Res. Section Abstract Doc Link 11720731 Disease Relevance 0.34 Pain Relevance 1.35
These results indicate that morphine does not inhibit prostaglandin synthetase but may modify the effect of prostaglandin.
Negative_regulation (inhibit) of prostaglandin synthetase associated with morphine
3) Confidence 0.20 Published 1978 Journal Arzneimittelforschung Section Abstract Doc Link 312105 Disease Relevance 0.43 Pain Relevance 1.10
Furthermore, the decrease in Hsp70 in the CR mice is indicative of increased apoptosis, since the presence of Hsp prevents the recruitment of caspase 9 to the apoptosome [81].
Negative_regulation (decrease) of CR associated with apoptosis
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.23 Pain Relevance 0.11
Conversely, PC was lower in CR vs.
Negative_regulation (lower) of CR
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2827549 Disease Relevance 0.68 Pain Relevance 0.08
PC was lower in CR vs.
Negative_regulation (lower) of CR
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0 Pain Relevance 0
In contrast to the effect of CR on increasing MDA, protein oxidation following CR is decreased in G93A mice.
Negative_regulation (effect) of CR
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.42 Pain Relevance 0
In contrast to the effect of CR on increasing MDA, protein oxidation following CR is decreased in G93A mice.
Negative_regulation (decreased) of CR
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.41 Pain Relevance 0
Acetaminophen (ACET) is also an effective analgesic and may selectively inhibit brain prostaglandin synthetase.
Spec (may) Negative_regulation (inhibit) of prostaglandin synthetase in brain associated with paracetamol and analgesic
9) Confidence 0.05 Published 2005 Journal Pharmacology Section Abstract Doc Link 15775706 Disease Relevance 0.39 Pain Relevance 1.51
Prostaglandin synthetase activity of bovine seminal vesicles and mouse macrophages was inhibited by the compounds at 10(-5) M concentrations.
Negative_regulation (inhibited) of Prostaglandin synthetase in macrophages
10) Confidence 0.04 Published 1990 Journal Acta Pharm Nord Section Abstract Doc Link 2095797 Disease Relevance 0.55 Pain Relevance 0.12

General Comments

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