INT19831

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Context Info
Confidence 0.08
First Reported 1986
Last Reported 1990
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 7
Disease Relevance 3.33
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptgis) extracellular space (Ptgis) endoplasmic reticulum (Ptgis)
Anatomy Link Frequency
platelet 4
coronary artery 2
Ptgis (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 8 98.36 Very High Very High Very High
agonist 2 97.64 Very High Very High Very High
antagonist 14 91.56 High High
adenocard 10 82.00 Quite High
Angina 12 79.28 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 20 99.84 Very High Very High Very High
Myocardial Infarction 17 98.18 Very High Very High Very High
Increased Venous Pressure Under Development 5 94.96 High High
Thrombosis Related Under Development 5 94.40 High High
Cv General 3 Under Development 12 79.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because all patients with myocardial infarction were receiving intravenous heparin and nitroglycerin, which might interfere with platelet prostacyclin binding, competition experiments were performed in vitro.
prostacyclin Spec (might) Binding (binding) of in platelet associated with myocardial infarction
1) Confidence 0.08 Published 1986 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 3016061 Disease Relevance 0.59 Pain Relevance 0.20
In this study, specific binding of prostacyclin to intact platelets was determined in patients with coronary artery disease by direct binding studies using 9-3H-prostacyclin sodium salt.
prostacyclin Binding (binding) of in coronary artery associated with coronary artery disease
2) Confidence 0.08 Published 1986 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 3016061 Disease Relevance 0.70 Pain Relevance 0.20
L-Epinephrine in concentrations up to 10 microM also exhibited no competition with specific platelet prostacyclin binding.
prostacyclin Binding (binding) of in platelet
3) Confidence 0.06 Published 1986 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 3016061 Disease Relevance 0.46 Pain Relevance 0.12
Platelet prostacyclin binding in coronary artery disease.
prostacyclin Binding (binding) of in coronary artery associated with coronary artery disease
4) Confidence 0.06 Published 1986 Journal J. Am. Coll. Cardiol. Section Title Doc Link 3016061 Disease Relevance 0.78 Pain Relevance 0.20
Neither heparin (3 to 250 IU/ml) nor nitroglycerin (0.8 to 22 microM) displaced specifically bound 9-3H-prostacyclin.
prostacyclin Binding (bound) of
5) Confidence 0.06 Published 1986 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 3016061 Disease Relevance 0.49 Pain Relevance 0.18
Thromboxane synthase inhibitors increase the formation of PGD2 and prostacyclin, but also enhance the accumulation of the potent platelet agonist PGH2. 3.
prostacyclin Binding (formation) of in platelet associated with agonist
6) Confidence 0.00 Published 1990 Journal Z Kardiol Section Abstract Doc Link 2099038 Disease Relevance 0.15 Pain Relevance 0.46
Aspirin irreversibly inhibits TXA2 and PGH2 synthesis in platelets, but also reduces the formation of the platelet-inhibiting PGD2 and prostacyclin--even under a low-dose regimen. 2.
prostacyclin Binding (formation) of in platelet associated with aspirin
7) Confidence 0.00 Published 1990 Journal Z Kardiol Section Abstract Doc Link 2099038 Disease Relevance 0.16 Pain Relevance 0.40

General Comments

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