INT198357

Context Info Confidence 0.03 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0.17

extracellular space (Igf1) extracellular region (Igf1)

Igf1 (Mus musculus)

Pain Link Frequency Relevance Heat Somatostatin 14 99.50 imagery 1 94.12 tolerance 2 81.60 agonist 2 72.08 Pain 4 5.00 headache 3 5.00 visual analogue scale 2 5.00 abdominal pain 2 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Acromegaly 24 97.04 Cancer 4 92.76 Impaired Glucose Tolerance 1 81.60 Adenoma 3 25.68 Disease 2 8.00 Pain 4 5.00 Skin Appendage Disease 3 5.00 Headache 3 5.00 Abdominal Pain 2 5.00 Diarrhoea 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Eligible patients had responded to somatostatin analogues, defined as a reduction in GH of 50% or more from baseline, normalization of IGF-1 or a reduction of 30% or more, after a minimum period of 2 months of treatment.

Negative_regulation (reduction) of Localization (normalization) of IGF-1 associated with somatostatin

1) Confidence 0.03 Published 2006 Journal Clinical Endocrinology Section Body Doc Link PMC1618957 Disease Relevance 0.51 Pain Relevance 0.17

General Comments

This test has worked.