INT198387

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.29
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SRD5A1) small molecule metabolic process (SRD5A1) endoplasmic reticulum (SRD5A1)
cytoplasm (SRD5A1)
Anatomy Link Frequency
brain 1
SRD5A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 27 100.00 Very High Very High Very High
Pain 38 99.84 Very High Very High Very High
Morphine 106 99.48 Very High Very High Very High
Opioid 12 94.80 High High
Lasting pain 2 87.84 High High
Analgesic 4 67.08 Quite High
depression 24 50.00 Quite Low
opioid receptor 4 36.48 Quite Low
opiate 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 40 99.84 Very High Very High Very High
Cognitive Disorder 6 97.04 Very High Very High Very High
Benign Prostatic Hypertrophy 104 95.32 Very High Very High Very High
Alopecia 10 67.92 Quite High
Depression 35 64.00 Quite High
Anxiety Disorder 20 62.08 Quite High
Overactive Bladder 23 58.88 Quite High
Disease 8 57.16 Quite High
Urinary Tract Infection 3 56.56 Quite High
Incontinence 4 53.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus modulation of the enzymes 5-alpha reductase and aromatase has to be considered an important gateway to these functions.
Regulation (modulation) of 5-alpha reductase
1) Confidence 0.60 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.17 Pain Relevance 0.26
The Medical Therapy of Prostate Symptoms (MTOPS) study was designed to evaluate the long-term efficacy of the alpha-adrenergic receptor antagonist doxazosin and the 5-alpha-reductase inhibitor finasteride, whether taken as monotherapy or in combination, in preventing or delaying the progression of BPH.47 MTOPS randomized 3047 men at least 50 years of age with moderate to severe symptoms of BPH based on AUASS who had no previous medical, surgical, or experimental interventions for BPH into one of four groups: doxazosin alone, finasteride alone, placebo, and the combination of finasteride and doxazosin.
Spec (whether) Regulation (efficacy) of 5-alpha-reductase associated with benign prostatic hypertrophy and antagonist
2) Confidence 0.26 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778433 Disease Relevance 0.62 Pain Relevance 0.05
Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats

Background

Regulation (modulation) of 5-alpha reductase associated with pain and morphine
3) Confidence 0.12 Published 2010 Journal Mol Pain Section Title Doc Link PMC2978140 Disease Relevance 0.19 Pain Relevance 0.95
Animal studies suggested that finasteride could alter 5alpha-reductase activity in some regions of the brain, and lead to behavioral and mood changes.
Regulation (alter) of 5alpha-reductase in brain
4) Confidence 0.05 Published 2006 Journal BMC Clin Pharmacol Section Body Doc Link PMC1622749 Disease Relevance 0.32 Pain Relevance 0

General Comments

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