INT19843

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Context Info
Confidence 0.48
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.58
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
follicle 2
pituitary 2
thyroid gland 2
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 8 100.00 Very High Very High Very High
Opioid 8 100.00 Very High Very High Very High
Enkephalin 2 99.86 Very High Very High Very High
Endogenous opioid 3 99.84 Very High Very High Very High
narcan 12 99.30 Very High Very High Very High
Dopamine 2 99.04 Very High Very High Very High
mu opioid receptor 2 96.92 Very High Very High Very High
agonist 5 93.40 High High
antagonist 7 92.36 High High
Morphine 1 72.16 Quite High
Disease Link Frequency Relevance Heat
Hemorrhage 1 77.20 Quite High
Aging 5 75.00 Quite High
Substance Withdrawal Syndrome 3 59.44 Quite High
Death 1 58.04 Quite High
Body Weight 4 56.92 Quite High
Anxiety Disorder 5 44.40 Quite Low
Weight Gain 7 43.48 Quite Low
Pressure And Volume Under Development 18 40.92 Quite Low
Hirsutism 5 22.16 Low Low
Acne 13 21.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In males low doses of naloxone reduced plasma LH levels 10 to 40 min after injection (saline: 2.0 +/- 0.3 ng/ml plasma and 0.5 ng naloxone/kg: 1.1 +/- 0.3 ng/ml), whereas a decrease in plasma LH levels occurred 80 to 140 min after injection of high doses of naloxone (saline: 2.1 +/- 0.2 ng/ml and 2 mg naloxone/kg: 1.0 +/- 0.2 ng/ml).
Positive_regulation (occurred) of Negative_regulation (decrease) of LH in plasma associated with narcan
1) Confidence 0.48 Published 1990 Journal J. Dev. Physiol. Section Abstract Doc Link 2099379 Disease Relevance 0.06 Pain Relevance 0.56
We conclude that in red deer hinds, seasonal regulation of LH secretion does not involve dopamine or endogenous opioids and the thyroid gland is required specifically for LH suppression in the absence of estradiol.
Positive_regulation (required) of Negative_regulation (suppression) of LH in thyroid gland associated with dopamine and endogenous opioid
2) Confidence 0.41 Published 1998 Journal Biol. Reprod. Section Abstract Doc Link 9746749 Disease Relevance 0 Pain Relevance 0.51
Hence the suppression of Prl and LH by dexamethasone must be partly mediated by endogenous opioids, which must therefore inhibit pituitary secretion of Prl.
Positive_regulation (mediated) of Negative_regulation (suppression) of LH in pituitary associated with endogenous opioid and dexamethasone
3) Confidence 0.10 Published 1999 Journal Horm. Res. Section Abstract Doc Link 10352398 Disease Relevance 0 Pain Relevance 0.52
The increment in mu opioid receptors presumably renders the opioid target cells supersensitive to either residual beta-endorphin or other endogenous mu ligands, such as met-enkephalin, thus resulting in chronic opioid suppression of the pattern of LHRH release, and subsequently that of LH.
Positive_regulation (resulting) of Negative_regulation (suppression) of LH associated with mu opioid receptor, enkephalin and opioid
4) Confidence 0.09 Published 1995 Journal Exp. Gerontol. Section Abstract Doc Link 7556506 Disease Relevance 0.38 Pain Relevance 0.55
The decrease in the number of days without steroid ingestion should result in constant suppression of LH and follicle-stimulating hormone (FSH) levels and prevent follicular growth during the hormone-free interval.
Positive_regulation (result) of Negative_regulation (suppression) of LH in follicle
5) Confidence 0.03 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971718 Disease Relevance 0.14 Pain Relevance 0.03

General Comments

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