INT19847

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Context Info
Confidence 0.70
First Reported 1988
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 13.89
Pain Relevance 4.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) extracellular space (Alb) extracellular region (Alb)
enzyme binding (Alb) DNA binding (Alb) protein complex (Alb)
Anatomy Link Frequency
muscle 4
urine 4
Hepatocyte 2
brain 2
small intestine 2
Alb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 26 99.72 Very High Very High Very High
ischemia 12 99.60 Very High Very High Very High
Inflammation 50 99.36 Very High Very High Very High
Restless leg syndrome 12 99.24 Very High Very High Very High
Paracetamol 10 99.04 Very High Very High Very High
Inflammatory marker 33 98.88 Very High Very High Very High
fibrosis 4 96.96 Very High Very High Very High
lidocaine 1 96.88 Very High Very High Very High
Inflammatory response 13 93.68 High High
isoflurane 5 92.96 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 204 99.84 Very High Very High Very High
Edema 2 99.68 Very High Very High Very High
Cv Unclassified Under Development 12 99.60 Very High Very High Very High
Frostbite 3 99.50 Very High Very High Very High
INFLAMMATION 104 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 13 99.24 Very High Very High Very High
Coronary Artery Disease 4 98.76 Very High Very High Very High
Injury 19 98.72 Very High Very High Very High
Hypertension 80 98.48 Very High Very High Very High
Weight Loss 28 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This revealed a bilateral increase in leucocyte-endothelial adhesion and vascular permeability to albumin after unilateral subtotal ischaemia and muscle stimulation, associated with increased urinary albumin excretion.
Positive_regulation (increased) of Localization (excretion) of albumin in muscle associated with cv unclassified under development and adhesions
1) Confidence 0.70 Published 1993 Journal Br J Surg Section Abstract Doc Link 8443644 Disease Relevance 0.64 Pain Relevance 0.24
However, transient exercise-induced muscle ischaemia results in systemic vascular endothelial injury associated with increased vascular permeability manifest as an increase in urinary albumin excretion.
Positive_regulation (increase) of Localization (excretion) of albumin in muscle associated with injury, cv unclassified under development and edema
2) Confidence 0.67 Published 1994 Journal Eur J Vasc Surg Section Abstract Doc Link 8181617 Disease Relevance 0.80 Pain Relevance 0.09
We found that by 1 month, necrosis of the papilla was complete, glomerular filtration rate was depressed, and urine albumin excretion was increased.
Positive_regulation (increased) of Localization (excretion) of albumin in urine associated with necrosis
3) Confidence 0.65 Published 1999 Journal Am. J. Kidney Dis. Section Abstract Doc Link 10352190 Disease Relevance 0.96 Pain Relevance 0.17
These animals showed a transient increase in urine flow rate, sodium and albumin excretion with maximum 30-60 min after resuscitation, while GFR and lithium clearance were normal.
Positive_regulation (increase) of Localization (excretion) of albumin in urine
4) Confidence 0.64 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9338510 Disease Relevance 1.07 Pain Relevance 0.13
By contrast, rats pretreated with acetaminophen for 2 months and exposed to Cd showed a marked increase in urinary excretion of albumin and beta 2-microglobulin, suggesting an interaction between both treatments.
Positive_regulation (increase) of Localization (excretion) of albumin associated with paracetamol
5) Confidence 0.57 Published 1988 Journal Arch. Toxicol. Section Abstract Doc Link 3071304 Disease Relevance 0.22 Pain Relevance 0.88
Gentle manipulation (3 min) of the stomach or the small intestine following laparotomy leads to an increase in albumin extravasation in the stomach, duodenum, jejunum and colon over 1 h.
Positive_regulation (increase) of Localization (extravasation) of albumin in small intestine
6) Confidence 0.49 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10443577 Disease Relevance 0 Pain Relevance 0
Bovine serum albumin (BSA) was used as a protein standard at concentrations ranging from 0.2 ?
Positive_regulation (concentrations) of Localization (used) of serum albumin
7) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0
Bovine serum albumin (BSA) was used as a protein standard at concentrations ranging from 0.2 ?
Positive_regulation (Bovine) of Localization (used) of serum albumin
8) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0
In contrast to this finding and closer to our own results, modest weight reduction in the intensive lifestyle group of the Diabetes Prevention Program did not reduce albumin excretion significantly (39).


Neg (not) Positive_regulation (reduce) of Localization (excretion) of albumin associated with weight loss and diabetes mellitus
9) Confidence 0.33 Published 2010 Journal European Journal of Endocrinology Section Body Doc Link PMC2950661 Disease Relevance 1.25 Pain Relevance 0.04
Albumin excretion was increased in diabetic animals and even more in hypertensive rats; combination of both diseases did not further elevate albuminuria (figure 1C).
Positive_regulation (increased) of Localization (excretion) of Albumin associated with diabetes mellitus, hypertension, disease and albuminuria
10) Confidence 0.28 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.35 Pain Relevance 0
The increase in albumin secretion was statistically significant in each rLSEC-PEM-Hepatocyte cultures in comparison to hepatocyte monolayers with p-values lower than 0.05.
Positive_regulation (increase) of Localization (secretion) of albumin in Hepatocyte
11) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980491 Disease Relevance 0 Pain Relevance 0
BP, serum creatinine, and urinary albumin excretion were significantly higher in SNX than in sham rats.
Positive_regulation (higher) of Localization (excretion) of albumin
12) Confidence 0.23 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 14600034 Disease Relevance 0.35 Pain Relevance 0.08
Urinary albumin excretion, previously demonstrated to reflect vascular permeability, increased significantly after exercise in claudicants and was associated with decreased neutrophil filterability and increased serum lysozyme activity.
Positive_regulation (increased) of Localization (excretion) of albumin in neutrophil
13) Confidence 0.22 Published 1990 Journal Br J Surg Section Abstract Doc Link 2100988 Disease Relevance 0.41 Pain Relevance 0.33
Chronic oral administration of OKY-046 ameliorated not only the renal hyperperfusion but increased urinary albumin excretion (UAE) at two weeks, but also the renal hypoperfusion, filtration fraction and UAE at 24 weeks.
Positive_regulation (increased) of Localization (excretion) of albumin
14) Confidence 0.20 Published 1994 Journal Kidney Int. Section Abstract Doc Link 8196281 Disease Relevance 0.54 Pain Relevance 0.16
change of the N-terminus of albumin, leading to a reduction in its binding with
Positive_regulation (leading) of Localization (terminus) of albumin
15) Confidence 0.19 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2375971 Disease Relevance 1.09 Pain Relevance 0.30
Indeed, increased urinary albumin excretion can be a marker of coexisting coronary artery disease in patients with peripheral arterial disease (22).
Positive_regulation (increased) of Localization (excretion) of albumin in coronary artery associated with coronary artery disease and peripheral arterial disease
16) Confidence 0.15 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518358 Disease Relevance 1.93 Pain Relevance 0.05
Glucose, protein, albumin, and NAG excretion were not significantly increased after anesthesia.
Neg (not) Positive_regulation (increased) of Localization (excretion) of albumin
17) Confidence 0.14 Published 1998 Journal Anesthesiology Section Body Doc Link 9523801 Disease Relevance 0 Pain Relevance 0
Transcranial cold injury in rats and guinea pigs induced cerebral extravasation of albumin labeled with Evans blue dye or 125I, respective indicators of the area and amount of blood-brain barrier (BBB) disruption.
Positive_regulation (induced) of Localization (extravasation) of albumin in brain associated with frostbite
18) Confidence 0.10 Published 1990 Journal J. Neurotrauma Section Abstract Doc Link 2127946 Disease Relevance 0.34 Pain Relevance 0
These changes, as well as the increased albumin excretion seen in this model, were also ameliorated by treatment with either an angiotensin receptor blocker or an angiotensin converting enzyme inhibitor [9].
Positive_regulation (increased) of Localization (excretion) of albumin
19) Confidence 0.05 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1435876 Disease Relevance 0.95 Pain Relevance 0
During the acute phase of inflammatory states, there are quantifiable increases in C-reactive protein, white blood cell count, and fibrinogen, and decreases in serum albumin [5–8].
Positive_regulation (increases) of Localization (decreases) of serum albumin in white blood cell associated with inflammation
20) Confidence 0.05 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1160573 Disease Relevance 1.45 Pain Relevance 0.18

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