INT198478

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2006
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 0.54
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ranbp2) protein folding (Ranbp2) transport (Ranbp2)
nucleus (Ranbp2) intracellular (Ranbp2)
Ranbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 189 97.56 Very High Very High Very High
Glutamate 9 49.08 Quite Low
tolerance 54 5.00 Very Low Very Low Very Low
anesthesia 36 5.00 Very Low Very Low Very Low
cerebral cortex 18 5.00 Very Low Very Low Very Low
ketamine 18 5.00 Very Low Very Low Very Low
imagery 18 5.00 Very Low Very Low Very Low
addiction 9 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 18 79.84 Quite High
Parkinson's Disease 27 77.76 Quite High
Hyperglycemia 18 74.04 Quite High
Stress 9 63.80 Quite High
Diabetes Mellitus 27 58.24 Quite High
Neurodegenerative Disease 9 53.36 Quite High
Aging 18 49.84 Quite Low
Sprains And Strains 18 34.96 Quite Low
Impaired Glucose Tolerance 36 5.00 Very Low Very Low Very Low
Body Weight 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since RanBP2 exhibits chaperone activity, we assessed whether the interaction between the LD of RanBP2 and Cox11 was direct and the chaperone activity of LD toward folding species of Cox11.
RanBP2 Spec (whether) Binding (interaction) of
1) Confidence 0.48 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
On the other hand, the cell (tissue)-selective interaction of RanBP2 with some of its partners may also impart cell-restricted roles to RanBP2.
RanBP2 Binding (interaction) of
2) Confidence 0.37 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.07 Pain Relevance 0
This chaperone function is likely to be complemented by other partners of RanBP2 with similar and pleiotropic functions.
RanBP2 Spec (likely) Binding (complemented) of
3) Confidence 0.37 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
A diverse set of additional molecular partners, each associating specifically with a selective domain of RanBP2, are likely to impart and integrate additional roles to RanBP2.
RanBP2 Binding (associating) of
4) Confidence 0.37 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0.10
Yet, the significance of these interactions with RanBP2 and the genetic and physiological role(s) of RanBP2 in a whole-animal model remain elusive.
RanBP2 Binding (interactions) of
5) Confidence 0.36 Published 2006 Journal PLoS Genetics Section Abstract Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
with the Ran-binding domains of RanBP2 [10,11], may mediate the nuclear translocation of multifunctional substrates, such as glyceraldehyde-3-phosphate dehydrogenase.
RanBP2 Binding (binding) of
6) Confidence 0.36 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.39 Pain Relevance 0.11
Several molecular partners with distinct functions interacting specifically with selective modules of RanBP2 have been identified.
RanBP2 Binding (interacting) of
7) Confidence 0.36 Published 2006 Journal PLoS Genetics Section Abstract Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
RanBP2 associates in vitro and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11, and the pacemaker of glycolysis, hexokinase type I (HKI) via its leucine-rich domain.
RanBP2 Binding (associates) of
8) Confidence 0.36 Published 2006 Journal PLoS Genetics Section Abstract Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
The specific interaction of RanBP2 with a diverse set of partners likely reflects a pleiotropic role of RanBP2 in cell function, possibly through the integration of multiple pathways.
RanBP2 Binding (interaction) of
9) Confidence 0.36 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.08 Pain Relevance 0

General Comments

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