INT198494

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ranbp2) protein folding (Ranbp2) transport (Ranbp2)
nucleus (Ranbp2) intracellular (Ranbp2)
Anatomy Link Frequency
dopaminergic neurons 1
Ranbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 42 95.92 Very High Very High Very High
tolerance 12 76.96 Quite High
Glutamate 2 16.16 Low Low
Hippocampus 2 13.60 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Body Weight 4 80.80 Quite High
Impaired Glucose Tolerance 8 77.60 Quite High
Diabetes Mellitus 6 34.80 Quite Low
Parkinson's Disease 6 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low
Diabetic Retinopathy 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the impact of RanBP2 haploinsufficiency on the utilization, formation, and uptake of glucose, we carried out several physiological assays.
Spec (determine) Regulation (impact) of RanBP2
1) Confidence 0.45 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.16 Pain Relevance 0.31
In this regard, it will be interesting to probe whether parkin also causes deficits in HKI in dopaminergic neurons, since parkin was reported to modulate RanBP2 turnover [20], and parkin loss-of-function also causes energy and growth deficits [26–29,42].
Regulation (modulate) of RanBP2 in dopaminergic neurons
2) Confidence 0.27 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0.04

General Comments

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