INT198501

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0.92
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ranbp2) protein folding (Ranbp2) transport (Ranbp2)
nucleus (Ranbp2) intracellular (Ranbp2)
Anatomy Link Frequency
retina 1
brain 1
hippocampus 1
Ranbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 8 98.92 Very High Very High Very High
Central nervous system 168 91.92 High High
imagery 16 89.48 High High
Glutamate 8 88.40 High High
anesthesia 32 45.24 Quite Low
ketamine 16 24.40 Low Low
cerebral cortex 16 16.72 Low Low
tolerance 48 5.00 Very Low Very Low Very Low
addiction 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 16 99.66 Very High Very High Very High
Diabetes Mellitus 24 97.52 Very High Very High Very High
Disseminated Intravascular Coagulation 8 70.84 Quite High
Ganglion Cysts 8 66.44 Quite High
Hyperglycemia 16 63.44 Quite High
Congenital Anomalies 8 59.96 Quite High
Stress 8 58.72 Quite High
Impaired Glucose Tolerance 32 5.00 Very Low Very Low Very Low
Parkinson's Disease 24 5.00 Very Low Very Low Very Low
Body Weight 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the levels of RanBP2 were decreased in the retina, brain, and hippocampus of RanBP2+/?
Negative_regulation (decreased) of RanBP2 in retina associated with hippocampus
1) Confidence 0.43 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.13 Pain Relevance 0.16
The data support that the ultimate pathophysiological outcome in HKI, caused by a reduction in RanBP2 levels and its chaperone activity, is the selective degradation of HKI as reflected by the reduced levels of HKI (and ATP) but not of other mitochondrial and NPC components (Figure 5).
Negative_regulation (reduction) of RanBP2
2) Confidence 0.43 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
A feeder-independent mouse ES cell line derived from the 129P2/OlaHsd strain and harboring a disrupted RanBP2 locus by insertion mutagenesis with the gene trap vector, pGT0pfs [67,68] (generated by W.
Negative_regulation (disrupted) of RanBP2 associated with sprains and strains
3) Confidence 0.43 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.16 Pain Relevance 0.04
Generation of a mouse line with a disrupted RanBP2 locus and histological analysis of trapped RanBP2 mice.
Negative_regulation (disrupted) of RanBP2
4) Confidence 0.43 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.16 Pain Relevance 0.07
The data herein show tissues with a decrease of RanBP2 and HKI levels mirror a reduction in the ATP levels.
Negative_regulation (decrease) of RanBP2
5) Confidence 0.43 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.22 Pain Relevance 0.19
The partial loss of the RanBP2 chaperone activity in RanBP2+/?
Negative_regulation (loss) of RanBP2
6) Confidence 0.38 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
Although the levels of RanBP2 were decreased in the retina, brain, and hippocampus of RanBP2+/?
Negative_regulation (decreased) of RanBP2 in hippocampus associated with hippocampus
7) Confidence 0.15 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.13 Pain Relevance 0.16
Although the levels of RanBP2 were decreased in the retina, brain, and hippocampus of RanBP2+/?
Negative_regulation (decreased) of RanBP2 in brain associated with hippocampus
8) Confidence 0.15 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.13 Pain Relevance 0.16

General Comments

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