INT198505

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.49
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ranbp2) protein folding (Ranbp2) transport (Ranbp2)
nucleus (Ranbp2) intracellular (Ranbp2)
Anatomy Link Frequency
fat 2
neurons 2
Ranbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 18 98.88 Very High Very High Very High
addiction 3 98.16 Very High Very High Very High
Central nervous system 63 81.16 Quite High
anesthesia 12 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 12 98.88 Very High Very High Very High
Metabolic Disorder 3 92.60 High High
Diabetes Mellitus 9 91.44 High High
Diabetic Retinopathy 3 89.96 High High
Body Weight 6 66.04 Quite High
Parkinson's Disease 9 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hyperglycemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mice on a higher fat diet (~10% fat) performed significantly worse in the glucose tolerance test beginning at 6 mo of age (Figure 7A and 7B), thus supporting that the RanBP2+/?
Positive_regulation (supporting) of Gene_expression (/) of RanBP2 in fat associated with tolerance and impaired glucose tolerance
1) Confidence 0.50 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.16 Pain Relevance 0.31
Cox 11 Inhibits HKI Activity and the LD of RanBP2 Reverses the Inhibition of Cox11 over HKI
Positive_regulation (over) of Gene_expression (over) of RanBP2
2) Confidence 0.50 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
In light of the prominent expression of RanBP2 and HKI in retinal neurons [1,19], the vital dependence of the neuronal retina (and brain) on glucose as the main substrate source for energy production, and the determinant impact of metabolic disorders, such as diabetes, in retinal function (e.g., diabetic retinopathy) [37], we probed the impact of deficits in RanBP2, HKI, and ATP, on the electrophysiological responses of subclasses (rod and cone) photoreceptor and postreceptor retinal neurons of RanBP2+/?
Spec (determinant) Positive_regulation (prominent) of Gene_expression (expression) of RanBP2 in neurons associated with addiction, metabolic disorder, diabetes mellitus and diabetic retinopathy
3) Confidence 0.50 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.33 Pain Relevance 0.12

General Comments

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