INT198506

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.63
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ranbp2) protein folding (Ranbp2) transport (Ranbp2)
nucleus (Ranbp2) intracellular (Ranbp2)
Anatomy Link Frequency
retina 4
photoreceptor 2
brain 1
hippocampus 1
Ranbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 7 98.92 Very High Very High Very High
Central nervous system 147 92.32 High High
addiction 7 75.24 Quite High
tolerance 42 50.48 Quite High
anesthesia 28 45.24 Quite Low
ketamine 14 24.40 Low Low
cerebral cortex 14 15.96 Low Low
imagery 14 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Retinopathy 7 83.84 Quite High
Diabetes Mellitus 21 81.88 Quite High
Metabolic Disorder 7 81.16 Quite High
Ganglion Cysts 7 66.84 Quite High
Congenital Anomalies 7 60.36 Quite High
Impaired Glucose Tolerance 28 27.00 Quite Low
Parkinson's Disease 21 5.00 Very Low Very Low Very Low
Sprains And Strains 14 5.00 Very Low Very Low Very Low
Body Weight 14 5.00 Very Low Very Low Very Low
Aging 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the levels of RanBP2 were decreased in the retina, brain, and hippocampus of RanBP2+/?
Negative_regulation (decreased) of Gene_expression (levels) of RanBP2 in retina associated with hippocampus
1) Confidence 0.43 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.13 Pain Relevance 0.16
The data support that the ultimate pathophysiological outcome in HKI, caused by a reduction in RanBP2 levels and its chaperone activity, is the selective degradation of HKI as reflected by the reduced levels of HKI (and ATP) but not of other mitochondrial and NPC components (Figure 5).
Negative_regulation (reduction) of Gene_expression (levels) of RanBP2
2) Confidence 0.43 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
The scotopic (dark-adapted) responses mediated by the rod photoreceptor pathway at low-stimulus intensities and mixed rod and cone pathways at high-stimulus intensities were substantially reduced in RanBP2+/?
Negative_regulation (reduced) of Gene_expression (/) of RanBP2 in photoreceptor
3) Confidence 0.43 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.25 Pain Relevance 0.06
The partial loss of the RanBP2 chaperone activity in RanBP2+/?
Negative_regulation (loss) of Gene_expression (activity) of RanBP2
4) Confidence 0.43 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
The partial loss of the RanBP2 chaperone activity in RanBP2+/?
Negative_regulation (loss) of Gene_expression (activity) of RanBP2
5) Confidence 0.37 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
Although the levels of RanBP2 were decreased in the retina, brain, and hippocampus of RanBP2+/?
Negative_regulation (decreased) of in brain Gene_expression (levels) of RanBP2 in retina associated with hippocampus
6) Confidence 0.15 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.13 Pain Relevance 0.16
Although the levels of RanBP2 were decreased in the retina, brain, and hippocampus of RanBP2+/?
Negative_regulation (decreased) of in hippocampus Gene_expression (levels) of RanBP2 in retina associated with hippocampus
7) Confidence 0.15 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.13 Pain Relevance 0.16

General Comments

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