INT198515

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.33
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HK1) mitochondrion (HK1) small molecule metabolic process (HK1)
nucleolus (HK1) nucleus (HK1) carbohydrate metabolic process (HK1)
Anatomy Link Frequency
neurons 2
HK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 2 98.48 Very High Very High Very High
tolerance 12 79.20 Quite High
Central nervous system 42 39.12 Quite Low
anesthesia 8 10.04 Low Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Disorder 2 92.92 High High
Diabetes Mellitus 6 91.76 High High
Diabetic Retinopathy 2 90.28 High High
Impaired Glucose Tolerance 8 55.72 Quite High
Body Weight 4 24.00 Low Low
Parkinson's Disease 6 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In light of the prominent expression of RanBP2 and HKI in retinal neurons [1,19], the vital dependence of the neuronal retina (and brain) on glucose as the main substrate source for energy production, and the determinant impact of metabolic disorders, such as diabetes, in retinal function (e.g., diabetic retinopathy) [37], we probed the impact of deficits in RanBP2, HKI, and ATP, on the electrophysiological responses of subclasses (rod and cone) photoreceptor and postreceptor retinal neurons of RanBP2+/?
Spec (determinant) Regulation (light) of Gene_expression (expression) of HKI in neurons associated with addiction, metabolic disorder, diabetes mellitus and diabetic retinopathy
1) Confidence 0.18 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.33 Pain Relevance 0.12
Regardless, lower levels of HKI likely contribute to the decreased levels in ATP, slower growth rates, and diminished ability to metabolize glucose of RanBP2+/?
Regulation (contribute) of Gene_expression (levels) of HKI
2) Confidence 0.18 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0

General Comments

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