INT198536

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.08
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cox11, HK1) small molecule metabolic process (HK1) carbohydrate metabolic process (HK1)
transmembrane transport (HK1) cytosol (HK1) nucleolus (HK1)
Cox11 (Mus musculus)
HK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 24 84.20 Quite High
Central nervous system 126 70.08 Quite High
ketamine 12 63.36 Quite High
cerebral cortex 12 25.28 Quite Low
tolerance 36 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 12 76.24 Quite High
Aging 12 34.96 Quite Low
Diabetic Retinopathy 6 7.32 Low Low
Diabetes Mellitus 18 5.36 Low Low
Impaired Glucose Tolerance 24 5.00 Very Low Very Low Very Low
Parkinson's Disease 18 5.00 Very Low Very Low Very Low
Body Weight 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Hyperglycemia 12 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cox11 strongly inhibits HKI activity in a concentration-dependent fashion, and at ~15 nM of Cox11, HKI activity could not be recorded (Figure 2A).
Cox11 Negative_regulation (inhibits) of HKI
1) Confidence 0.22 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
As shown in Figure 2C, the LD domain sharply reversed the inhibitory effect of Cox11 on HKI activity in a concentration-dependent manner, but under saturating (and stochiometric) amounts of LD, the velocity of the reaction did not reach that observed for HKI activity in the absence of Cox11 (Figure 2A), suggesting the LD by itself may also have an effect on HKI activity.
Cox11 Negative_regulation (effect) of HKI
2) Confidence 0.16 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
The sub-stochiometry effect of the LD of RanBP2 over the inhibition of HKI by Cox11 supports that a LD-dependent chaperonin-like mechanism underlies the suppression of Cox11-dependent inhibition of HKI by RanBP2, and that RanBP2 acts as a molecular “buffer” over HK1 and Cox11 activities.
Cox11 Negative_regulation (inhibition) of HKI
3) Confidence 0.16 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0.11
Cox11 is a strong inhibitor of HKI, and RanBP2 suppresses the inhibitory activity of Cox11 over HKI.
Cox11 Negative_regulation (inhibitor) of HKI
4) Confidence 0.14 Published 2006 Journal PLoS Genetics Section Abstract Doc Link PMC1626108 Disease Relevance 0.08 Pain Relevance 0.04
Cox11 inhibits noncompetitively the activity of HKI with ~2–3 molecules of Cox11 (assuming formation of Cox11 dimer) required to inhibit completely the activity of a molecule of HKI (Figure 2A and 2B).
Cox11 Negative_regulation (inhibits) of HKI
5) Confidence 0.12 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0.27
Cox11 behaves as a partial noncompetitive inhibitor of HKI by affecting the Vmax of HKI for glucose (Figure 2B).
Cox11 Spec (partial) Negative_regulation (inhibitor) of HKI
6) Confidence 0.12 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0

General Comments

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