INT198537

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.05
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HK1, Ranbp2) isomerase activity (Ranbp2) transport (Ranbp2)
mitochondrion (HK1) small molecule metabolic process (HK1) intracellular (Ranbp2)
Anatomy Link Frequency
stem 1
HK1 (Homo sapiens)
Ranbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 6 80.56 Quite High
anesthesia 12 13.48 Low Low
Central nervous system 63 5.00 Very Low Very Low Very Low
tolerance 18 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 3 53.84 Quite High
Ganglion Cysts 3 40.48 Quite Low
Impaired Glucose Tolerance 12 5.00 Very Low Very Low Very Low
Diabetes Mellitus 9 5.00 Very Low Very Low Very Low
Parkinson's Disease 9 5.00 Very Low Very Low Very Low
Sprains And Strains 6 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Hyperglycemia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To probe whether the interaction of Cox11 and HKI with the LD of RanBP2 modulates the enzymatic activity of HKI, we first examined the effect of increasing concentrations of Cox11 on the initial rates of HKI enzymatic activity (Figure 2A).
HKI Spec (whether) Binding (interaction) of RanBP2
1) Confidence 0.22 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0
To determine the physiological implications of the interaction between RanBP2 and HKI (and other partners), we employed a murine embryonic stem 129Ola cell line with a targeted RanBP2 locus produced by gene-trapping to produce stable inbred (coisogenic) and mixed background lines, respectively (Figure 4A and 4B).
HKI Binding (interaction) of RanBP2 in stem
2) Confidence 0.16 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0.05 Pain Relevance 0.04
Through this process, it is also possible that deficits in RanBP2 cause a disturbance in the equilibrium between Cox11, HK1, and RanBP2 by leading to an increase of the inhibitory activity of Cox11 over HKI that promotes the uncoupling of the interaction of HKI from RanBP2, ultimately causing HKI degradation.
HKI Binding (interaction) of RanBP2
3) Confidence 0.16 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1626108 Disease Relevance 0 Pain Relevance 0

General Comments

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