INT19856

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2010
Negated 9
Speculated 6
Reported most in Abstract
Documents 240
Total Number 246
Disease Relevance 147.86
Pain Relevance 26.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T cells 106
lymphocytes 24
macrophages 5
cytotoxic T cells 3
blood 3
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1328 100.00 Very High Very High Very High
rheumatoid arthritis 820 99.80 Very High Very High Very High
Osteoarthritis 40 99.72 Very High Very High Very High
Morphine 14 99.68 Very High Very High Very High
Acupuncture 176 99.60 Very High Very High Very High
agonist 334 99.36 Very High Very High Very High
lidocaine 33 99.34 Very High Very High Very High
chemokine 428 99.32 Very High Very High Very High
Arthritis 326 99.22 Very High Very High Very High
Leflunomide 340 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 2713 100.00 Very High Very High Very High
Diffuse Cutaneous Leishmaniasis 2073 100.00 Very High Very High Very High
Cancer 1747 100.00 Very High Very High Very High
Leishmaniasis 1422 100.00 Very High Very High Very High
Necrosis 96 100.00 Very High Very High Very High
Adhesions 76 100.00 Very High Very High Very High
Lymphocytosis 8 100.00 Very High Very High Very High
Viral Infection 156 99.96 Very High Very High Very High
Infection 2427 99.90 Very High Very High Very High
Lymphatic System Cancer 134 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that Tyr-MIF-1 does not directly modulate CD 2, CD 4 and CD 8 expression, does not alter the proliferative response of PBL, and does not affect the production of IL 2.
Gene_expression (expression) of CD 8 in PBL
1) Confidence 0.75 Published 1989 Journal Brain Res. Bull. Section Abstract Doc Link 2575445 Disease Relevance 0 Pain Relevance 0.34
Expressions of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+), CD3(-)CD16(+)CD56(+), and CD3(+)CD25(+) were measured as percentages of total lymphocytes by flow cytometer at 5 time points.
Gene_expression (Expressions) of CD8 in lymphocytes
2) Confidence 0.75 Published 2006 Journal Clin. Chim. Acta Section Body Doc Link 16487501 Disease Relevance 0.08 Pain Relevance 0
We present a rare case of adult T cell leukemia (ATL) in which leukemic T cells simultaneously expressed CD4 and CD8 surface antigens and refractory cytomegalovirus (CMV)-induced gastroenterocolitis preceded its clinical onset.
Gene_expression (expressed) of CD8 in T cell associated with t-cell leukemia, cytomegalovirus infection and htlv types i and ii
3) Confidence 0.74 Published 1999 Journal Int. J. Hematol. Section Abstract Doc Link 10071457 Disease Relevance 0.94 Pain Relevance 0.09
APL with CD8 expression has never been reported.
Gene_expression (expression) of CD8 associated with acute promyelocytic leukemia
4) Confidence 0.71 Published 1996 Journal Rinsho Ketsueki Section Abstract Doc Link 8997125 Disease Relevance 1.08 Pain Relevance 0.10
[CD2 and CD8 expression in acute promyelocytic leukemia].
Gene_expression (expression) of CD8 associated with acute promyelocytic leukemia
5) Confidence 0.71 Published 1996 Journal Rinsho Ketsueki Section Title Doc Link 8997125 Disease Relevance 0.73 Pain Relevance 0.12
It leads to MHC-restricted clonal expansion of CD8 T cells characterized by circulating CD8 hyperlymphocytosis and CD8 T-cell infiltration in organs.
Gene_expression (infiltration) of CD8 in T-cell
6) Confidence 0.67 Published 2010 Journal Muscle Nerve Section Abstract Doc Link 19882634 Disease Relevance 1.10 Pain Relevance 0.10
It leads to MHC-restricted clonal expansion of CD8 T cells characterized by circulating CD8 hyperlymphocytosis and CD8 T-cell infiltration in organs.
Gene_expression (hyperlymphocytosis) of CD8 in T-cell
7) Confidence 0.67 Published 2010 Journal Muscle Nerve Section Abstract Doc Link 19882634 Disease Relevance 1.09 Pain Relevance 0.09
Morphine also inhibited CD8+ T cell-induced expression of the signal transducer and activator of transcription-1, an important transcriptional factor in the IFN signaling pathway.
Gene_expression (expression) of CD8 in T cell associated with morphine
8) Confidence 0.66 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16000393 Disease Relevance 0.87 Pain Relevance 0.78
Examination of immunological parameters revealed a transient decrease in CD25(+) peripheral blood lymphocytes and, in seven of eight patients, an increase in CD4(+):CD8(+) ratios at 2 weeks.
Gene_expression (ratios) of CD8 in lymphocytes
9) Confidence 0.65 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815786 Disease Relevance 0.84 Pain Relevance 0.09
His laboratory evaluation was negative for human immunodeficiency virus infection but flow cytometry revealed low CD4(+) count of 39 cells/mm(3) and CD4:CD8 ratio of 0.43.
Gene_expression (ratio) of CD8 associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.65 Published 2008 Journal Allergy Asthma Proc Section Abstract Doc Link 18702891 Disease Relevance 1.04 Pain Relevance 0.20
High dose methotrexate-leucovorin was associated with a significant reduction in DR antigen expression on peripheral Leu 2, Leu 3 and Leu 4 lymphocytes.
Gene_expression (expression) of Leu 2 in lymphocytes associated with methotrexate
11) Confidence 0.65 Published 1988 Journal J. Rheumatol. Section Abstract Doc Link 3258915 Disease Relevance 0.34 Pain Relevance 0.30
The aim of this study was to quantify the CD8+ CD28-compartment in a cohort of AS patients in comparison with a healthy control group, and to correlate the level of these cells with clinical parameters of disease progression and seropositivity to EBV and CMV.


Gene_expression (quantify) of CD8 associated with spinal inflammation, cytomegalovirus infection, epstein-barr virus and disease progression
12) Confidence 0.63 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 1.79 Pain Relevance 0.47
In our study, the levels of CD8+ CD28- T cells were not correlated with the age of the subjects, whereas others had observed an accumulation of CD8+ CD28-T cells in the elderly, including centenarians [12,13,14].
Gene_expression (levels) of CD8 in T cells
13) Confidence 0.63 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 1.04 Pain Relevance 0.35
CD8+ T lymphocyte depletion was monitored by flow cytometry prior to infection and CD8 depletion and weekly thereafter.
Gene_expression (depletion) of CD8 in T lymphocyte associated with infection
14) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.10 Pain Relevance 0
We longitudinally examined a group of rhesus macaques infected with SIV and CD8+ cell depleted (n?
Gene_expression (cell) of CD8
15) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.58 Pain Relevance 0.03
The concentrations of lymphocytes expressing the cluster designation (CD) cell-surface antigens CD3, CD4, CD8, and CD14 became elevated during exercise, and these responses were enhanced by hypoxia (P < or = 0.01).
Gene_expression (expressing) of CD8 in lymphocytes associated with hypoxia
16) Confidence 0.60 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 7759444 Disease Relevance 0.41 Pain Relevance 0.24
METHODS: The levels of beta-endorphin, methionine-enkephalin, epinephrin, norepinephrin (NE), dopamine, corticotropin releasing factor (CRF), adrenocoricotropic hormone (ACTH), cortisol, CD4/CD8 ratio, CD57, NK cell activity and IL-6 in the peripheral blood, which are considered to reflect the activity of this neuroendocrine-immune network, were measured and compared between 49 patients with rheumatoid arthritis (RA) and 54 healthy control subjects.
Gene_expression (levels) of CD8 in blood
17) Confidence 0.58 Published 2000 Journal Clin. Exp. Rheumatol. Section Body Doc Link 11072598 Disease Relevance 0.10 Pain Relevance 0
Proportions of CD8+ (panel a) and CD4+ (panel b) T cells expressing intracellular IFN-?
Gene_expression (Proportions) of CD8 in T cells
18) Confidence 0.58 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.58 Pain Relevance 0.12
Quantitation of the ex vivo CD8+ T-cell population specific for Gag, Tat, and Env in the systemic tissues of both animals revealed that, in contrast to the blood, the highest virus-specific CD8+ T-cell response was found in most tissues of animal 819, challenged by the intravenous route (Figs. 3 and 4 and Table).
Gene_expression (response) of CD8 in T-cell
19) Confidence 0.58 Published 2001 Journal BMC Infect Dis Section Body Doc Link PMC37356 Disease Relevance 0.24 Pain Relevance 0
Virus-specific CD8+ T-cell response in the blood
Gene_expression (response) of CD8 in blood
20) Confidence 0.58 Published 2001 Journal BMC Infect Dis Section Body Doc Link PMC37356 Disease Relevance 0.19 Pain Relevance 0

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