INT198568

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 2006
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 16.26
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DCPS) mitochondrion (DCPS) nucleolus (DCPS)
nucleus (DCPS) cytoplasm (DCPS)
Anatomy Link Frequency
blood 8
plasma 1
lymph nodes 1
DCs 1
epithelial cells 1
DCPS (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 5 99.42 Very High Very High Very High
Inflammation 311 98.40 Very High Very High Very High
tolerance 5 95.92 Very High Very High Very High
depression 16 95.20 Very High Very High Very High
Multiple sclerosis 20 93.60 High High
Pain 16 92.44 High High
Chronic pancreatitis 95 91.60 High High
medulla 50 81.84 Quite High
Lasting pain 3 77.64 Quite High
agonist 11 74.00 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 726 100.00 Very High Very High Very High
Cold Sores 203 100.00 Very High Very High Very High
Infection 139 100.00 Very High Very High Very High
Prostate Cancer 46 99.96 Very High Very High Very High
Disease 126 99.80 Very High Very High Very High
Cancer 476 99.68 Very High Very High Very High
Pancreatic Cancer 63 99.38 Very High Very High Very High
INFLAMMATION 314 98.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 94 97.96 Very High Very High Very High
Skin Cancer 55 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The failure of DCs and other providers for that matter, to address the removable causes of disease in patients and communities is no longer professionally acceptable.
Regulation (failure) of DCs associated with disease
1) Confidence 0.34 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1626475 Disease Relevance 0.41 Pain Relevance 0.09
DCs play a critical role for the induction of innate and adaptive antitumor immune responses.
Regulation (role) of DCs
2) Confidence 0.09 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 1.72 Pain Relevance 0
Much evidence exists regarding the fact that blood DCs, both myeloid DCs (MDCs) and plasmacytoid DCs (PDCs), are negatively affected in different types of cancer, with both reduced numbers and impaired functionality.
Regulation (affected) of DCs in blood associated with cancer
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955544 Disease Relevance 0.72 Pain Relevance 0.06
Much evidence exists regarding the fact that blood DCs, both myeloid DCs (MDCs) and plasmacytoid DCs (PDCs), are negatively affected in different types of cancer, with both reduced numbers and impaired functionality.
Regulation (affected) of DCs in blood associated with cancer
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955544 Disease Relevance 0.72 Pain Relevance 0.06
Much evidence exists regarding the fact that blood DCs, both myeloid DCs (MDCs) and plasmacytoid DCs (PDCs), are negatively affected in different types of cancer, with both reduced numbers and impaired functionality.
Regulation (affected) of DCs in blood associated with cancer
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2955544 Disease Relevance 0.72 Pain Relevance 0.06
Dexamethasone has been shown to adversely affect the function of monocyte-derived DCs (Woiciechowsky et al 1998; van den Heuval et al 1999; Ogden et al 2006) and can enhance DCs mediated tolerance.
Regulation (affect) of DCs in monocyte associated with tolerance and dexamethasone
6) Confidence 0.05 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727883 Disease Relevance 0.97 Pain Relevance 0.22
Accornero and collaborators concluded that the use of an inion-neck montage did not carry an extra risk since heart rate, blood pressure and body temperature remained unchanged during tDCS and 20 minutes after in healthy volunteers [20].
Neg (unchanged) Regulation (unchanged) of tDCS in blood
7) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0.06 Pain Relevance 0.10
This issue is crucial since it has been suggested that the current flow direction relative to the neuronal elements may be one of the key factors driving the effects of tDCS [7-13].
Regulation (effects) of tDCS in neuronal
8) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0.63 Pain Relevance 0.24
Our results prove that solid pancreatic tumors, including PDAC, systemically affect blood DCs.
Regulation (affect) of DCs in blood associated with adenocarcinoma and pancreatic cancer
9) Confidence 0.05 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2847547 Disease Relevance 2.25 Pain Relevance 0.38
Chronic N. americanus infection alters the host's innate immune response, resulting in a possible modulation of the maturation process of DCs, a functional change that may diminish their ability for antigen presentation and thus contribute to the ablation of the parasite-specific T cell proliferative response.
Spec (possible) Regulation (modulation) of DCs in T cell associated with infection
10) Confidence 0.04 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2654967 Disease Relevance 0.65 Pain Relevance 0.03
We examined the effect of single PDAC plasma from patients, PC021, PC045, and PC065 on purified blood DCs.
Spec (examined) Regulation (effect) of DCs in plasma associated with adenocarcinoma
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.54 Pain Relevance 0
Over time, there was no change in mature DCs.
Neg (no) Regulation (change) of DCs in DCs
12) Confidence 0.04 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2936306 Disease Relevance 0.15 Pain Relevance 0
Possible explanations for the stagnant number of mature DCs include immune regulation in the vaccination site microenvironment or migration of mature DCs to draining lymph nodes.
Regulation (regulation) of DCs in lymph nodes
13) Confidence 0.04 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0 Pain Relevance 0.04
One strategy is to target DCs in vivo by an anti-DC-specific Ab conjugated to relevant antigens.
Regulation (target) of DCs
14) Confidence 0.03 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.40 Pain Relevance 0
While epithelial cells are the major targets for HSV-2 infection, human [15], [16] and macaque [17] DCs are susceptible to HSV-2 infection in vitro resulting in the down-modulation of their immunostimulatory functions.
Regulation (targets) of DCs in epithelial cells associated with cold sores and infection
15) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2787245 Disease Relevance 1.93 Pain Relevance 0.06
Despite the use of diluted (1:4) patient plasma, we were able to confirm some of the markers that were altered on blood DCs in PDAC patients.


Regulation (altered) of DCs in blood associated with adenocarcinoma
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.73 Pain Relevance 0.09
Our results indicate that the PDAC patients with the best clinical outcome retained high expression of ICOSL on both MDCs and PDCs and CCR2 on PDCs, which indicate that the DCs were less affected by the tumor.
Regulation (affected) of DCs associated with adenocarcinoma and cancer
17) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.66 Pain Relevance 0.09
Our results prove that solid pancreatic tumors, including PDAC, systemically affect blood DCs.


Regulation (affect) of DCs in blood associated with adenocarcinoma and pancreatic cancer
18) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.95 Pain Relevance 0.09
No change in the percentage of pDCs was observed in the peripheral blood of any of these patients.
Neg (No) Regulation (change) of pDCs in blood
19) Confidence 0.02 Published 2011 Journal J Neuroinflammation Section Abstract Doc Link PMC3022734 Disease Relevance 1.05 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox