INT198595

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.36
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFH, CFHR1) extracellular region (CFH, CFHR1)
Anatomy Link Frequency
blood 1
CFH (Homo sapiens)
CFHR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 2 55.76 Quite High
headache 6 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 192 98.88 Very High Very High Very High
Disorder Of Lipid Metabolism 4 91.60 High High
Recurrence 4 86.84 High High
Disease 20 86.40 High High
Lyme Disease 44 82.88 Quite High
Cv General 3 Under Development 2 55.76 Quite High
Myocardial Infarction 6 54.64 Quite High
Pressure And Volume Under Development 16 53.12 Quite High
Infection 36 50.00 Quite Low
Hemolytic Uremic Syndrome 28 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of this was the observation that the presence of factor H-related protein 1 (encoded by CFHL1) in the serum of normal controls is polymorphic, with 4.4% of healthy blood donors having complete deficiency [12].
factor H Binding (presence) of CFHL1 in blood
1) Confidence 0.41 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.23 Pain Relevance 0
There is already evidence that nonallelic recombination leading to deletion of CFHL1 occurs as a common polymorphism in the general population [12], and we here show that this phenomenon also leads to the formation of a hybrid CFH/CFHL1 gene associated with aHUS.
aHUS Binding (associated) of CFHL1
2) Confidence 0.36 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.16 Pain Relevance 0.03
Taken together, binding of CFHR1 and CFHR2 to borrelial cells expressing CRASP-3 and CRASP-5 was more pronounced than that of CFH and CFHR5.


CFH Binding (binding) of CFHR1
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.43 Pain Relevance 0
Most likely the CFHR proteins cooperate with CFH.
CFH Binding (cooperate) of CFHR
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.24 Pain Relevance 0
Binding of CFHR1, CFHR2, and CFHR5 to native and recombinant CRASP-3 and CRASP-5 proteins was more pronounced than that of CFH.
CFH Binding (Binding) of CFHR1
5) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.23 Pain Relevance 0
Furthermore, CFHR1 which lacks C3-mediated cofactor activity but inhibits C5 convertase activity and MAC assembly might compete under physiological conditions with CFH for CRASP-3 and CRASP-5 binding (CFHR1:CFH ratio of 0.37:1) and thus reduce local CFH-mediated complement regulatory activity [28], [56].
CFH Binding (binding) of CFHR1
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox