INT198606

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 4.37
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFH) extracellular region (CFH)
CFH (Homo sapiens)
Pain Link Frequency Relevance Heat
vagus nerve 3 72.88 Quite High
headache 7 48.04 Quite Low
midbrain 11 46.80 Quite Low
depression 4 17.64 Low Low
corticosteroid 1 16.68 Low Low
withdrawal 2 13.80 Low Low
cINOD 6 9.24 Low Low
medulla 37 5.00 Very Low Very Low Very Low
Dopamine 11 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 102 100.00 Very High Very High Very High
Hemolytic Uremic Syndrome 39 100.00 Very High Very High Very High
Injury 256 99.84 Very High Very High Very High
Flavivirus Infection 160 99.84 Very High Very High Very High
Syncope 69 99.76 Very High Very High Very High
Necrosis 25 98.12 Very High Very High Very High
Dengue 208 93.32 High High
Frailty 1 92.44 High High
Infection 104 89.64 High High
Sprains And Strains 144 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CFH gDNA sequencing was undertaken as previously described [6] apart from exon 23, where the primers used were: forward 5?
Localization (sequencing) of CFH gDNA
1) Confidence 0.65 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0.70 Pain Relevance 0
In a panel of 80 patients with aHUS, three further individuals were identified by MLPA as having a deletion of CFH exons 22 and 23.
Localization (deletion) of CFH
2) Confidence 0.65 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1626556 Disease Relevance 0 Pain Relevance 0
Once complement is activated by the borreliae, it seems that the inhibitory activity of CFHR1 on the C5 convertase and the cofactor activity for factor I-mediated inactivation of C3b by CFHR5 can not completely retard formation and insertion of the MAC pointing to an crucial role of human CFH in complement resistance of borreliae.
Localization (role) of CFH
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0 Pain Relevance 0
A goat polyclonal antiserum was used to detect human CFH (Merck Biosciences, Bad Soden, Germany and Complement Technology, Tyler, TE).
Localization (detect) of CFH
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.14 Pain Relevance 0
The final wash and the elute fraction were separated by Glycine-SDS-PAGE and after transfer to nitrocellulose, presence of CFH was analyzed by immunoblot with a specific mAb.
Spec (analyzed) Localization (presence) of CFH
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958145 Disease Relevance 0.24 Pain Relevance 0
Functional landscape and modular organization of the HF PPI network
Localization (organization) of HF associated with myocardial infarction
6) Confidence 0.24 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 0.10 Pain Relevance 0
Taken together, these data suggests that AP regulatory proteins such as factor H and factor D, as well as their substrates, are potential therapeutic targets to prevent the onset of DHF.



Localization (onset) of factor H associated with flavivirus infection
7) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.69 Pain Relevance 0
Purified human factor H (Calbiochem), a goat polyclonal antiserum against human factor H (Calbiochem), a mouse monoclonal antiserum [HYB 268] against human factor H (Abcam), and HRP-conjugated goat anti-mouse IgG (Jackson Immunoresearch) were used to measure factor H.
Localization (measure) of factor H
8) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.05 Pain Relevance 0
HUS is a common cause of AKI in children and leads to substantial morbidity and mortality rates and long-term complications that may not become apparent until adulthood [58].
Localization (cause) of HUS associated with injury and hemolytic uremic syndrome
9) Confidence 0.09 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.97 Pain Relevance 0
Within the NCS group, HF-HRV was significantly positively correlated with fainting frequency [r = ? 
Localization (correlated) of HF-HRV associated with syncope
10) Confidence 0.04 Published 2009 Journal Neuroimage Section Body Doc Link PMC2726440 Disease Relevance 0.48 Pain Relevance 0.04

General Comments

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