INT198653

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.81
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, MIF) extracellular region (TNF, MIF) isomerase activity (MIF)
intracellular (TNF) extracellular matrix organization (TNF) cytoplasm (MIF)
TNF (Homo sapiens)
MIF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 426 99.08 Very High Very High Very High
cytokine 447 97.44 Very High Very High Very High
Arthritis 3 60.36 Quite High
Inflammatory mediators 3 46.72 Quite Low
rheumatoid arthritis 3 21.56 Low Low
Crohn's disease 3 20.56 Low Low
Inflammatory response 30 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 69 99.78 Very High Very High Very High
INFLAMMATION 462 99.08 Very High Very High Very High
Disease 291 98.40 Very High Very High Very High
Hypoglycemia 18 97.20 Very High Very High Very High
Sepsis 225 93.04 High High
Malaria 630 92.60 High High
Acidosis 48 76.08 Quite High
Stress 9 73.76 Quite High
Acid Base Imbalance 84 65.36 Quite High
Arthritis 3 60.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As with HIF-1, both hypoxia [273] and TNF [42] upregulate MIF.
TNF Positive_regulation (upregulate) of MIF associated with hypoxia
1) Confidence 0.15 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.58 Pain Relevance 0.21
For example, TNF induces migration inhibitory factor (MIF) [42,43], and TNF, IL-1 beta and LT generate the inducible form of nitric oxide synthase iNOS [44].
TNF Positive_regulation (induces) of migration inhibitory factor
2) Confidence 0.15 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.12 Pain Relevance 0.67
For example, TNF induces migration inhibitory factor (MIF) [42,43], and TNF, IL-1 beta and LT generate the inducible form of nitric oxide synthase iNOS [44].
TNF Positive_regulation (induces) of MIF
3) Confidence 0.15 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.12 Pain Relevance 0.67

General Comments

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