INT198662

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 7.73
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (CD36) transport (CD36) small molecule metabolic process (CD36)
cell adhesion (CD36) Golgi apparatus (CD36) plasma membrane (CD36)
Anatomy Link Frequency
monocytes 3
Fat 1
hepatocyte 1
body 1
CD36 (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 219 99.84 Very High Very High Very High
rheumatoid arthritis 453 99.56 Very High Very High Very High
chemokine 127 98.04 Very High Very High Very High
agonist 135 91.60 High High
dexamethasone 6 90.96 High High
aspirin 9 87.72 High High
Inflammation 396 84.48 Quite High
ischemia 11 66.40 Quite High
cytokine 351 60.60 Quite High
Bile 8 7.08 Low Low
Disease Link Frequency Relevance Heat
Adhesions 51 100.00 Very High Very High Very High
Stress 27 100.00 Very High Very High Very High
Obesity 181 99.60 Very High Very High Very High
Rheumatoid Arthritis 529 99.56 Very High Very High Very High
Apoptosis 75 94.24 High High
Hypolipidemia 8 94.24 High High
Diabetes Mellitus 101 90.56 High High
Cancer 188 90.12 High High
Targeted Disruption 8 84.88 Quite High
Hypoglycemia 19 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the induction of CD36 by adalimumab was specific to the F(ab')2 portion.
Positive_regulation (induction) of CD36 associated with adalimumab
1) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.21
on the induction of CD36 mRNA by rosiglitazone.
Positive_regulation (induction) of CD36
2) Confidence 0.68 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.06
According to the results of our study, the increase in membrane expression of CD36 induced by adalimumab involves a redox signaling pathway via NADPH oxidase activation, but not PPAR?.
Positive_regulation (induced) of CD36 associated with adalimumab
3) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0.15 Pain Relevance 0.22
The CD36 glycoprotein, which plays a role in cellular adhesion and in the regulation of fatty acid transport and uptake, and participates in cellular control of oxidative stress by binding to oxidized low-density lipoprotein [15], was downregulated after 1-h exposure, but was upregulated after 6 h exposure to L. plantarum.
Positive_regulation (upregulated) of CD36 associated with stress and adhesions
4) Confidence 0.39 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.38 Pain Relevance 0
Preliminary experiments using the monocytic cell line U937 showed that CCL25 (0 to 500 ng/ml) induced differentiation of these cells as indicated by a concentration dependent increase of CD36 levels (P < 0.0001) (data not shown).
Positive_regulation (increase) of CD36
5) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.19 Pain Relevance 0.23
by enhancement of CD36 gene transcription [74].
Positive_regulation (enhancement) of CD36
6) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.98 Pain Relevance 0
ligands are capable of increasing CD36
Positive_regulation (increasing) of CD36
7) Confidence 0.27 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.86 Pain Relevance 0
target genes such as Cd36 were also induced by TRO treatment in lean mice without induction of PPAR?
Positive_regulation (induced) of Cd36
8) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 1.06 Pain Relevance 0
Several PPAR target genes, such as CYP4A1, CPT1, or CD36, were induced in the two hepatocyte cultures treated by 40??
Positive_regulation (induced) of CD36 in hepatocyte
9) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.14 Pain Relevance 0
and increased glucose transporter 4 (Glut4), muscle carnitine palmitoyl-transferase (Cat), stearoyl CoA desaturase (SCoA), and fatty acid translocase (Fat) in adipose tissue, while only Fat was slightly augmented in the liver which expresses very little hepatic PPAR?.
Positive_regulation (increased) of fatty acid translocase in Fat associated with obesity
10) Confidence 0.25 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.36 Pain Relevance 0.17
Among them, genes involved in lipid metabolism, such as FABP4 or CD36, were induced.
Positive_regulation (induced) of CD36
11) Confidence 0.23 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 0.21 Pain Relevance 0.05
There were significant increased levels of CD36 at all concentrations tested compared to the no chemokine control (P < 0.001 in each case).
Positive_regulation (increased) of CD36 associated with chemokine
12) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.38 Pain Relevance 0.31
PMA also gave a significant stimulation in CD36 levels compared to control (P < 0.001).
Positive_regulation (stimulation) of CD36
13) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.46 Pain Relevance 0.35
Addition of CXCL16 (the ligand for CXCR6) at 50, 100 and 500 ng/ml gave no significant increase in CD36 levels on RA and healthy monocytes for each concentration (Figure 5c, d).
Neg (no) Positive_regulation (increase) of CD36 in monocytes associated with rheumatoid arthritis
14) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945064 Disease Relevance 0.86 Pain Relevance 0.50
These include a ten-fold upregulation of adhesion molecules such as E- selectin by TNF [167], CD36 [122], intercellular adhesion molecule-1 (ICAM-1 CD54) and vascular cell adhesion molecule-1 (VCAM-1 CD106) [168] and, with implications for the observed accumulation of monocytes, monocyte chemotactic protein-1 (MCP-1) [169].
Positive_regulation (upregulation) of CD36 in monocyte associated with adhesions
15) Confidence 0.14 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.53 Pain Relevance 0.12
This lowering of lipids is mainly due to insulin-mediated inhibition of the hormone-sensitive lipase in adipose tissue, the determining enzyme for whole-body lipid fuel availability [30] and insulin-induced CD36-mediated increase in FFA uptake [31].
Positive_regulation (induced) of CD36 in body associated with obesity
16) Confidence 0.12 Published 2008 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2329728 Disease Relevance 0.65 Pain Relevance 0.03
These include a ten-fold upregulation of adhesion molecules such as E- selectin by TNF [167], CD36 [122], intercellular adhesion molecule-1 (ICAM-1 CD54) and vascular cell adhesion molecule-1 (VCAM-1 CD106) [168] and, with implications for the observed accumulation of monocytes, monocyte chemotactic protein-1 (MCP-1) [169].
Positive_regulation (upregulation) of CD36 in monocytes associated with adhesions
17) Confidence 0.05 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.53 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox