INT198663

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Context Info
Confidence 0.52
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 11.41
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HMGB1) extracellular space (HMGB1) extracellular region (HMGB1)
nucleolus (HMGB1) nucleus (HMGB1) DNA binding (HMGB1)
Anatomy Link Frequency
neutrophils 1
HMGB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 339 99.96 Very High Very High Very High
Inflammatory marker 52 99.96 Very High Very High Very High
cytokine 237 99.68 Very High Very High Very High
addiction 14 86.76 High High
Inflammatory response 48 78.68 Quite High
antagonist 1 73.12 Quite High
anesthesia 9 38.12 Quite Low
cva 4 29.64 Quite Low
Abeta 36 5.00 Very Low Very Low Very Low
fibrosis 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 278 100.00 Very High Very High Very High
Critical Illness 21 100.00 Very High Very High Very High
INFLAMMATION 409 99.96 Very High Very High Very High
Cancer 109 99.64 Very High Very High Very High
Sepsis 568 99.60 Very High Very High Very High
Communicable Diseases 27 99.00 Very High Very High Very High
Disease 153 96.84 Very High Very High Very High
Malaria 215 96.68 Very High Very High Very High
Pneumonia 34 92.72 High High
Apoptosis 47 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
POD 1 upregulation of PDGFA, ERG1, and HMGB1 mRNA correlated significantly with worse prognosis.
Positive_regulation (upregulation) of HMGB1
1) Confidence 0.52 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.26 Pain Relevance 0.11
In the study by Sunden-Cullberg and colleagues, the HMGB1 levels in critically ill patients remained elevated for up to 1 week, with mean levels of HMGB1 over 340 ng/ml after a 144-hour observation period [17].
Positive_regulation (elevated) of HMGB1 associated with critical illness
2) Confidence 0.50 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.80 Pain Relevance 0.10
Elevated levels of HMGB1, LBP and PCT were associated with the presence of infection and with the presence of bacteraemia in patients with community-acquired infections.
Positive_regulation (levels) of HMGB1 associated with infection
3) Confidence 0.46 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.95 Pain Relevance 0.07
Levels of all studied inflammatory markers (HMGB1, LBP, PCT, IL-6) and infection markers (C-reactive protein, white blood cell count, neutrophils) were elevated among bacteraemic patients.
Positive_regulation (elevated) of HMGB1 in neutrophils associated with inflammatory marker and infection
4) Confidence 0.46 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206511 Disease Relevance 0.74 Pain Relevance 0.09
In the study by Sunden-Cullberg and colleagues, the HMGB1 levels in critically ill patients remained elevated for up to 1 week, with mean levels of HMGB1 over 340 ng/ml after a 144-hour observation period [17].
Positive_regulation (elevated) of HMGB1 associated with critical illness
5) Confidence 0.46 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.80 Pain Relevance 0.10
HMGB1, along with RAGE, is upregulated in many tumor types (Table 2).
Positive_regulation (upregulated) of HMGB1 associated with cancer
6) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.77 Pain Relevance 0.11
HMGB1 binding to RAGE is enhanced with CpG DNA.
Positive_regulation (enhanced) of HMGB1
7) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.31 Pain Relevance 0.21
This is likely explains why HMGB1 is the only member of the family that activates RAGE [65].
Positive_regulation (activates) of HMGB1
8) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.07 Pain Relevance 0.04
We also evaluated serum HMGB1 for this purpose because there is abundant evidence supporting the role of HMGB1 as an inflammatory mediator, especially in sepsis (9, 10).
Positive_regulation (evaluated) of HMGB1 associated with inflammation and sepsis
9) Confidence 0.21 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967001 Disease Relevance 1.87 Pain Relevance 0.09
Levels of HMGB1, LBP and PCT were higher in the severe sepsis group compared with the sepsis group (P < 0.01).
Positive_regulation (higher) of HMGB1 associated with sepsis
10) Confidence 0.20 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206511 Disease Relevance 0.91 Pain Relevance 0.08
HMGB1 has been shown to be increased, in proportion to degree of illness, in serum from African children infected with falciparum malaria [57].
Positive_regulation (increased) of HMGB1 associated with malaria
11) Confidence 0.19 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.35 Pain Relevance 0.31
Several authors [8,27] have stated that in studies where blotting methods were used, higher levels of HMGB1 in range from 84 ng/ml to over 340 ng/ml were observed [9,25,26].
Positive_regulation (levels) of HMGB1
12) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2831899 Disease Relevance 0.85 Pain Relevance 0.03
Similar findings were reported by Hatada et al. [11] who detected moderately elevated HMGB1 levels in patients with infectious diseases and highest HMGB1 levels in patients who died.
Positive_regulation (elevated) of HMGB1 associated with communicable diseases
13) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2831899 Disease Relevance 0.94 Pain Relevance 0.12
In 1999, Wang et al [24] found increased levels of HMGB1 in 25 critically ill patients with sepsis, and significantly higher levels in those that succumbed to the disease.
Positive_regulation (increased) of HMGB1 associated with critical illness, disease and sepsis
14) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2831899 Disease Relevance 0.80 Pain Relevance 0.13

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