INT198669

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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.45
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBD) plasma membrane (THBD) embryo development (THBD)
Anatomy Link Frequency
endothelial cell 1
THBD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 351 99.08 Very High Very High Very High
cytokine 334 87.68 High High
ischemia 4 86.88 High High
cva 8 83.20 Quite High
Inflammatory response 48 82.64 Quite High
Inflammatory mediators 17 51.72 Quite High
Kinase C 10 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
vagus nerve 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 422 99.08 Very High Very High Very High
Hemolytic Anemia 1 99.08 Very High Very High Very High
Vasculitis 6 98.00 Very High Very High Very High
Hemorrhage 5 95.12 Very High Very High Very High
Adhesions 41 93.32 High High
Stress 46 92.96 High High
Cerebrovascular Disease 1 90.64 High High
Aneurism 2 89.68 High High
Brain Injury 2 88.96 High High
Necrosis 12 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, thrombin – thrombomodulin complex formation will be low in tissues where endothelial thrombomodulin is low.
thrombomodulin Binding (formation) of
1) Confidence 0.10 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.48 Pain Relevance 0.10
When bound to thrombomodulin, a thrombin receptor on the endothelial cell surface, thrombin activates protein C, which can degrade Factor VIIIa and Factor Va, essential cofactors in the activation of Factor X and prothrombin respectively [164].
thrombomodulin Binding (bound) of in endothelial cell
2) Confidence 0.10 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.36 Pain Relevance 0.24
The first case of HO-1 deficiency in human was identified in 1999 [14], the patient suffered persistent hemolytic anemia and abnormal coagulation/fibrinolysis system associated with elevated thrombomodulin and von Willebrand factor, indicating persistent vascular injury.
thrombomodulin Binding (associated) of associated with hemolytic anemia and vasculitis
3) Confidence 0.08 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.70 Pain Relevance 0.16
It regulates fibrinolysis by producing t-PA and its inhibitor PAI-1 and limits activation of the coagulation cascade by thrombomodulin/protein C, heparin sulphate/antithrombin and tissue factor/tissue factor inhibitor interactions.
thrombomodulin Binding (interactions) of
4) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.23 Pain Relevance 0.13
Interestingly, human soluble thrombomodulin (ART-123)
           can physically bind to HMGB1 protein, thereby inhibiting an HMGB1-mediated inflammatory
           response. 
thrombomodulin Binding (bind) of associated with inflammation
5) Confidence 0.05 Published 2008 Journal Expert Reviews in Molecular Medicine Section Body Doc Link PMC2586610 Disease Relevance 0.68 Pain Relevance 0.12

General Comments

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