INT198682

Context Info Confidence 0.49 First Reported 2002 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 2.61 Pain Relevance 0.37

Anatomy Link Frequency blood 1 Ifna (Mus musculus)

Pain Link Frequency Relevance Heat Potency 9 100.00 Pain 21 91.20 headache 8 82.16 cytokine 5 76.68 withdrawal 5 5.00 tolerance 3 5.00 alcohol 2 5.00 depression 1 5.00 Inflammation 1 5.00 pruritus 1 5.00

Disease Link Frequency Relevance Heat Ehrlichiosis 46 99.98 Toxicity 3 99.36 Infection 51 92.48 Immunization 44 91.72 Pain 22 91.20 Anaemia 1 88.60 Babesiosis 1 88.16 Lyme Disease 5 87.60 Fatigue 15 84.00 Vomiting 3 83.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The highest levels of IFAT response were generated after 3 immunizations with PfCS102 formulated with AS02A.

Positive_regulation (response) of IFA

1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749339 Disease Relevance 0.14 Pain Relevance 0.04

Since then, efforts aimed at increasing the adjuvant potency of IFA while reducing toxicity have led to new generations of highly purified mineral oils such as the Montanide incomplete Seppic adjuvants (ISAs) (Seppic, Paris, France) that have been approved for both human and veterinary use[11,12].

Positive_regulation (increasing) of IFA associated with toxicity and potency

2) Confidence 0.13 Published 2006 Journal J Transl Med Section Body Doc Link PMC1630705 Disease Relevance 0.48 Pain Relevance 0.14

The HGE IFA antibody titer remained elevated (>1:64) in one (1.4%) of 70 specimens tested.

Positive_regulation (elevated) of IFA associated with ehrlichiosis

3) Confidence 0.07 Published 2002 Journal Emerging Infectious Diseases Section Body Doc Link PMC2730236 Disease Relevance 1.50 Pain Relevance 0.19

To assess the statistical significance of titre increases (ELISA, IFA) after sporozoite challenge we used a Wilcoxon signed-rank test to compare titres before and after sporozoite challenge.

Positive_regulation (increases) of IFA

4) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2204057 Disease Relevance 0.16 Pain Relevance 0

Positive IFA results were obtained with sporozoites, but not with blood stage parasites.

Positive_regulation (results) of IFA in blood

5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2204057 Disease Relevance 0.34 Pain Relevance 0

General Comments

This test has worked.