INT198682

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.61
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
Ifna (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 9 100.00 Very High Very High Very High
Pain 21 91.20 High High
headache 8 82.16 Quite High
cytokine 5 76.68 Quite High
withdrawal 5 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ehrlichiosis 46 99.98 Very High Very High Very High
Toxicity 3 99.36 Very High Very High Very High
Infection 51 92.48 High High
Immunization 44 91.72 High High
Pain 22 91.20 High High
Anaemia 1 88.60 High High
Babesiosis 1 88.16 High High
Lyme Disease 5 87.60 High High
Fatigue 15 84.00 Quite High
Vomiting 3 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The highest levels of IFAT response were generated after 3 immunizations with PfCS102 formulated with AS02A.
Positive_regulation (response) of IFA
1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749339 Disease Relevance 0.14 Pain Relevance 0.04
Since then, efforts aimed at increasing the adjuvant potency of IFA while reducing toxicity have led to new generations of highly purified mineral oils such as the Montanide incomplete Seppic adjuvants (ISAs) (Seppic, Paris, France) that have been approved for both human and veterinary use[11,12].
Positive_regulation (increasing) of IFA associated with toxicity and potency
2) Confidence 0.13 Published 2006 Journal J Transl Med Section Body Doc Link PMC1630705 Disease Relevance 0.48 Pain Relevance 0.14
The HGE IFA antibody titer remained elevated (>1:64) in one (1.4%) of 70 specimens tested.
Positive_regulation (elevated) of IFA associated with ehrlichiosis
3) Confidence 0.07 Published 2002 Journal Emerging Infectious Diseases Section Body Doc Link PMC2730236 Disease Relevance 1.50 Pain Relevance 0.19
To assess the statistical significance of titre increases (ELISA, IFA) after sporozoite challenge we used a Wilcoxon signed-rank test to compare titres before and after sporozoite challenge.
Positive_regulation (increases) of IFA
4) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2204057 Disease Relevance 0.16 Pain Relevance 0
Positive IFA results were obtained with sporozoites, but not with blood stage parasites.
Positive_regulation (results) of IFA in blood
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2204057 Disease Relevance 0.34 Pain Relevance 0

General Comments

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