INT198738

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Context Info
Confidence 0.97
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.06
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
neurons 1
spine 1
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 85 97.40 Very High Very High Very High
long-term potentiation 4 20.16 Low Low
isoflurane 17 5.00 Very Low Very Low Very Low
Somatosensory cortex 12 5.00 Very Low Very Low Very Low
agonist 7 5.00 Very Low Very Low Very Low
Glutamate receptor 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Pyramidal cell 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Disease 5 55.20 Quite High
Fragile X Syndrome 21 50.00 Quite Low
Intellectual Impairment 9 41.80 Quite Low
Syndrome 3 28.52 Quite Low
Convulsion 4 8.64 Low Low
Autism 4 8.08 Low Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore individual PSD-95 molecules effectively hop from spine to spine, visiting dozens of PSDs before being degraded.
Protein_catabolism (degraded) of PSD-95 in spine
1) Confidence 0.97 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0
Degradation of PSD-95 (half-life ~ 36 h) is negligible over the time course of single imaging sessions (90 min) [23,41].
Protein_catabolism (Degradation) of PSD-95 associated with imagery
2) Confidence 0.97 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.05
Studies in cultured neurons suggest that the stability of PSD-95 at synapses can be modulated by synaptic activity [40–42,44].
Protein_catabolism (stability) of PSD-95 in neurons
3) Confidence 0.64 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.04
Stable sets of PSD-95 binding sites at individual PSDs could explain the stability of PSD-95 clusters.
Protein_catabolism (stability) of PSD-95
4) Confidence 0.56 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.03
FMRP has also been suggested to regulate PSD-95 mRNA stability [38].
Protein_catabolism (stability) of PSD-95 mRNA
5) Confidence 0.11 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.06 Pain Relevance 0

General Comments

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