INT198744

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 1.73
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
hypothalamus 4
cortex 2
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 2 95.04 Very High Very High Very High
Central nervous system 3 90.08 High High
imagery 42 87.44 High High
Pyramidal cell 5 83.04 Quite High
nMDA receptor 10 81.92 Quite High
monoamine 13 68.32 Quite High
Glutamate 6 63.92 Quite High
Neurotransmitter 9 63.12 Quite High
cytokine 3 61.60 Quite High
Glutamate receptor 20 43.92 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 128 99.64 Very High Very High Very High
Schizophrenia 39 95.40 Very High Very High Very High
Retts Disease 102 93.24 High High
Disease 39 92.08 High High
Aids-related Complex 10 81.20 Quite High
Congenital Anomalies 14 70.72 Quite High
Intellectual Impairment 8 65.52 Quite High
Manic Depressive Disorder 4 63.60 Quite High
Cognitive Disorder 17 61.48 Quite High
Mental Disorders 6 51.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 2B, the expression of PSD-95 in the hippocampal subfields was unaffected by the genetic manipulation and particularly in the stratum radiatum, where the electrophysiological experiments were carried out (described below), was normal.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (expression) of PSD-95
1) Confidence 0.42 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0.11
We measured PSD-95 clusters (Gmax of photoactivated PSD-95-paGFP) and ?
Negative_regulation (measured) of Gene_expression (clusters) of PSD-95-paGFP
2) Confidence 0.42 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.07
Surprisingly, we found that expression of postsynaptic density-95 (PSD95) and synaptophysin (Syp) was significantly downregulated in hypothalamus of Mecp2?
Negative_regulation (downregulated) of Gene_expression (expression) of PSD95 in hypothalamus
3) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.17 Pain Relevance 0
Surprisingly, we found that expression of postsynaptic density-95 (PSD95) and synaptophysin (Syp) was significantly downregulated in hypothalamus of Mecp2?
Negative_regulation (downregulated) of Gene_expression (expression) of postsynaptic density-95 in hypothalamus
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.17 Pain Relevance 0
The steady state level of PSD95 and Syp mRNAs in Mecp2?
Negative_regulation (level) of Gene_expression (mRNAs) of PSD95
5) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.17 Pain Relevance 0
Psychiatric disorders and PSD-95 complexes
Negative_regulation (disorders) of Gene_expression (complexes) of PSD-95
6) Confidence 0.36 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.58 Pain Relevance 0.04
We measured PSD-95 clusters (Gmax of photoactivated PSD-95-paGFP) and ?
Negative_regulation (measured) of Gene_expression (clusters) of PSD-95
7) Confidence 0.36 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.07
The KO mice also showed decreased expression of the NR1, PSD-95, p-CaMKII, and PAK families, and these signaling pathways are known to regulate synaptic structure and function in the developing cortex [43], [44], [45].
Negative_regulation (decreased) of Gene_expression (expression) of PSD-95 in cortex associated with targeted disruption
8) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.66 Pain Relevance 0.24

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