INT198748

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.16
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dlg4) plasma membrane (Dlg4) protein complex assembly (Dlg4)
cytoplasm (Dlg4)
Anatomy Link Frequency
spines 4
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 87 97.48 Very High Very High Very High
Glutamate receptor 52 95.44 Very High Very High Very High
medulla 5 95.04 Very High Very High Very High
monoamine 13 92.48 High High
Dynorphin 2 91.12 High High
imagery 22 89.12 High High
opiate 1 87.88 High High
Somatosensory cortex 4 87.04 High High
cytokine 4 85.76 High High
Hippocampus 37 84.60 Quite High
Disease Link Frequency Relevance Heat
Congenital Anomalies 16 100.00 Very High Very High Very High
Targeted Disruption 292 99.48 Very High Very High Very High
Disease 57 93.00 High High
Schizophrenia 78 84.52 Quite High
Repression 5 72.40 Quite High
Pain 10 61.60 Quite High
Intellectual Impairment 11 52.04 Quite High
Cognitive Disorder 19 50.60 Quite High
Depression 73 50.00 Quite Low
Anxiety Disorder 53 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, the physiological, biochemical, tissue and subcellular localization studies indicate that the presence of the TAP tag did not significantly alter the expression or function of PSD-95.


Regulation (function) of Gene_expression (expression) of PSD-95
1) Confidence 0.44 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.09 Pain Relevance 0.06
PSD-95 expression affects AMPA receptor-mediated excitatory synaptic transmission (Migaud et al, 1998; Beique et al, 2006; Carlisle et al, 2008) and is thought to involve indirect interactions through stargazin, SAP-97, Adam22, Lgi1 and Nsf (Leonard et al, 1998; Osten et al, 1998; Fukata et al, 2006).
Regulation (affects) of Gene_expression (expression) of PSD-95
2) Confidence 0.44 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.09 Pain Relevance 0.08
Together, the physiological, biochemical, tissue and subcellular localization studies indicate that the presence of the TAP tag did not significantly alter the expression or function of PSD-95.


Neg (not) Regulation (alter) of Gene_expression (expression) of PSD-95
3) Confidence 0.44 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.14 Pain Relevance 0.06
As shown in Figure 2B, the expression of PSD-95 in the hippocampal subfields was unaffected by the genetic manipulation and particularly in the stratum radiatum, where the electrophysiological experiments were carried out (described below), was normal.
Neg (unaffected) Regulation (unaffected) of Gene_expression (expression) of PSD-95
4) Confidence 0.44 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0.11
However, analysis of spine morphology and synaptic strength in brain slices harvested from the experimental mice revealed that, under our conditions, the expression of PSD-95-GFP in vivo did not change synaptic strength or spine size (Figure S1).
Neg (not) Regulation (change) of Gene_expression (expression) of PSD-95-GFP in spine
5) Confidence 0.44 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1634879 Disease Relevance 0 Pain Relevance 0.20
We found that the expression of PSD-95 is not changed in TgDREAM mice, however, co-immunoprecipitation experiments show that there is a direct interaction between DREAM and PSD-95.
Neg (not) Regulation (changed) of Gene_expression (expression) of PSD-95
6) Confidence 0.34 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.06 Pain Relevance 0.64
We found that PSD95 expression is not altered in neurabin KO mice (n?
Neg (not) Regulation (altered) of Gene_expression (expression) of PSD95 associated with targeted disruption
7) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.77 Pain Relevance 0.38
Thus, the morphological changes observed in dendritic spines may have been a result of the observed decreases in the expression of the NR1, PSD-95, p-CaMKII, and PAK families.
Regulation (result) of Gene_expression (expression) of PSD-95 in spines
8) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.66 Pain Relevance 0.19
Homozygous mice showed no detectable abnormalities in PSD-95 expression, subcellular localization or synaptic electrophysiological function.
Neg (no) Regulation (abnormalities) of Gene_expression (expression) of PSD-95 associated with congenital anomalies
9) Confidence 0.23 Published 2009 Journal Mol Syst Biol Section Abstract Doc Link PMC2694677 Disease Relevance 0.23 Pain Relevance 0.07
Both PSD-95 and FMRP mRNAs contain putative G-quartets in their 3?
Regulation (Both) of Gene_expression (mRNAs) of PSD-95
10) Confidence 0.09 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.12 Pain Relevance 0.05

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